复方丹参滴丸治疗老年心衰患者后血浆pro-bnp表达变化研究

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1、复方丹参滴丸治疗老年心衰患者后血浆pro-BNP表达变化研究王宁勃田刚雷坐邈魏迭罜鈕艺静西安交通大学医学院第一附属医院心血管内科铜川市人民医院南院心血管内科北京中医药大学第七临床医院内科铜川市人民医院南院消化内科铜川市人民医院南院内分泌科摘要：目的:探讨复方乃•参滴丸治疗老年心力衰竭(心衰)的临床疗效及对患者血浆B型利钠肽前体(proBNP)水平的影响。方法:将92例老年心衰患者随机分成对照组与观察组，每组46例。其中对照组给予常规丙医治疗，观察组在对照组的基础上加用复方丹参滴丸10粒/次，3次/天，2组疗程均为6个月。观察并记录2组患者治疗前及治疗1、3、6个月后血浆pro-BNP

2、水平变化情况，治疗6个月后的临床疗效及治疗期间不良反应的发生情况。结果:对照组治疗6个月后的血浆pro-BNP水平显著低于治疗前，差异有统计学意义;观察组治疗3、6个月后的血浆pro-BNP水平均显著低于治疗前，同时也显著低于对照组，差异有统计学意义;治疗6个月后观察组的临床疗为91.3%效显著优于对照组76.1%，差异奋统计学意义。结论:复方丹参滴丸治疗老年心衰能够有效降低患者的血浆pro-BNP水平，且疗效显著，安全可靠。关键词：复方丹参滴丸;老年心衰;B型利钠肽前体;作者简介：田刚，E-mail:1049741773@qq.com。收稿曰期:2017-09-01Clinical

3、effectofcompoundDanshendroppingpillsfortheelderlypatientswithheartfailureanditsinfluenceontheplasmapro-BNPWangNing-boTianGangLeiHua-binWeiTie-junGuoYi-anInternalMedicine-CardiovascularDepartmentTheFirstAffiliatedHospitalofXi’anJiaoTongUniversityMedicalCollege;InternalmedicineTheseventhClinicalH

4、ospitalofBeijingUniversityofChineseMedicine;GIMedicineTongchuanPeople’sHospital;EndocrineDepartmentTongchuanPeople’sHospital;Abstract：ObjectiveToinvestigatetheclinicaleffectofcompoundDanshendroppingpillstherapyinpatientswithcongestiveheartsfailure,andtoanalysisitseffectontheplasmapro-BNP.Method

5、sNinety-twopatientswithcongestiveheartsfailurewererandolydividedintocontrolgroupandobservationgroup,eachgroup46cases.Thecontrolgroupweretreatmentbyroutinewesternmedicine,andtheobservationgroupweretreatmentbycompoundDanshendroppingpills10pillsonetime,3timesoneday,onecourseofthetreatmentofeachgro

6、upissixmonths.ThenobservedanclrecordedtheleveloftheplasmaproBNPbeforeandone,three,sixmonthsaftertreatment,theclinicaleffectandtheadversereaction.ResultsTnthecontrolgroup,sixmonthsaftertreatment,theleveloftheplasmapro-BNPwassignificantlylowerthanthatbeforetreatment,astatisticallysignificantdiffe

7、rence-Inobservationgroup,threeandsixmonthsaftertreatment,theselevelsoftheplasmapro-BNPweresignificantlylowerthanthosebeforetreatment,andalsosignificantlylowerthanthoseinthecontrolgroup,astatisticallysignificantdifference.Sixmonths