糖尿病和糖尿病视网膜病变相关的自然发病啮齿动物模型

《糖尿病和糖尿病视网膜病变相关的自然发病啮齿动物模型》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、糖尿病和糖尿病视网膜病变相关的自然发病啮齿动物模型　　AbstractDiabetesisaplexandheterogeneousdisorderpresentlyaffectingmorethan100millionpeopleicproblems.Spontaneousrodentmodelsofdiabetesmellitushaveprovedinvaluableinunderstandingthepathogenesis,plications,andgeicorenvironmentalinfluencest

2、hatincreasetherisksofdiabetes.ODELSOFTYPE1DIABETES　　Thereareseveralspontaneousrodentmodelsoftype1diabetes,touse[4].　　NODMouseTheNODmousealaboratorystrainthatinfactent[5,6].Insulitisispresenticeare45munelesioninvolvinglymphocyticinfiltrationanddestructionofthepanc

3、reaticβcellsleadstohypoinsulinemia,hyperglycemia,ketoacidosis,anddeath.Thereisalargergenderdifferencealesand20%ofmalesdevelopingdiabetesinNODmice[7].　　Type1diabetesisapolygenicdisease.BothinhumanandinNODmousetype1diabetes,theprimarysusceptibilitygeneislocatedouse

4、representsprobablythebestspontaneousmodelusedingeicandimmunologicstudiesandseemsparticularlyanalogoustohumantype1diabetes.Ithasprovidednotonlyessentialinformationontype1diabetespathogenesis,butalsovaluableinsightsintomechanismsofimmunoregulationandtolerance.Import

5、antly,itallomunointerventionstrategiespotentiallyapplicabletoman[9,10].　　Type1BioBreedingRatModelsTheBioBreeding(BB)ratelyusefulforstudyingbothspontaneousdiabeticprone(BBDP)andinduceddiabeticresistant(BBDR)diabetesandassociateddiabeticplications[12].Asinhuman

6、type1diabetes,thesyndromeinBBratsischaracterizedbyhyperglycemia,lymphocyticinsulitis,andthepresenceofantibodiestoisletcellsurfacemolecules.Inmonouse,thepancreaticisletsaresubjectedtoanimmuneattackacrophagesandnaturalkillercellsbeingrecruitedtotheinsulitis[13,14];t

7、hesusceptibilitygeneislocatedicaciddecarboxylase(GAD),havebeenreportedinbothBBratsandtheNODmouse,althoughitremainsfarfromcleararyautoantigens[1618].　　Itisbelievedthatthedevelopmentofdiabetesinthemodelissecondarytoacellmediatedautoimmuneprocessandmayhaveimplicati

8、onsforthepathophysiologyoftype1diabetesinhumans.BBDPratsarepronetothelongtermplicationsofdiabetessuchasneuropathyandretinopathythatoccurinthismodelarev