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1、丙泊酚复合布托啡诺用于无痛人流手术的临床观察叶君1杨禄坤2方晓萍1(1珠海妇幼保健院麻醉科广东珠海519000；2中山大学附属第五医院麻醉科广东珠海519000)【摘要】目的探讨丙泊酚复合布托啡诺用于无痛人流手术的麻醉效果和安全性。方法门诊无痛人流手术孕妇50例，随机分为丙泊酚组(P组)和布托啡诺组(B组)，每组25例。P组静注丙泊酚3mg?kg-l,B组静注布托啡诺lmg+丙泊酪2.5mg·kg-l，待孕妇意识消失后开始手术，术中若体动影响手术则追加丙泊酚30mg。记录麻醉前(TO)、麻醉后2min(Tl),4min(T2)和手术结束时(T3)的MAP、HR和
2、SpO2;记录手术时间、苏醒时间、出院时间、丙泊酚用量、麻醉效果评级、不良反应(术中呼吸抑制、术后头晕、恶心呕吐)的发生情况和术后下腹痛VAS评分。结果丙泊酚用量B组低于P组(P<0.05);组内MAP和HR比较，两组Tl、T2高于T0(P<0.05};组间MAP和HR比较，B组在Tl、T2低于P组(P<0.05);两组SpO2组内组间比较差异均无统计学意义(P>0.05);麻醉效果和下腹痛VAS评分B组优于P组(P<0.05>,两组不良反应比较差异无统计学意义(P>0.05)。结论丙泊酚复合布托啡诺用于无痛人流手术可获得满意的麻醉效果，减
3、少丙泊酚用量，减轻术后下腹疼痛，不良反应发生率低。【关键词】丙泊酚布托啡诺无痛人流静脉全麻【中图分类号】R969【文献标识码】A【文章编号】2095-1752(2014)11-0020-02ClinicalobservationofpropofolcombinedwithbutorphanolonpainlessabortionsurgeryYEJunl,YANGLu-kun2,FANGXiao-pinl1.DepartmentofAnesthesiology,ZhuhaiMaternityandChildHealthhospital2.DepartmentofAnesthe
4、siology,theFifthAffiliatedHospitalofSunYat-senUniversity,Zhuhai,519000,China【Abstract】Objective:Toevaluatetheanestheticeffectandsafetyofpropofolcombinedwithbutorphanolonpainlessabortionsurgery.Methods:50pregnantwomenscheduledtoundergopainlessabortionsurgeryinoutpatientdepartmentwererandomly
5、dividedintotwogroups(n=25each):thepropofolgroup(groupP)andthebutorphanolgroup(groupB).ThepregnantwomeningroupPreceivedpropofol3mgkg-1i.v.'whilereceivedbutorphanol1mgandpropofol2.5mg.kg-1ingroupB.Theoperationwasbegunafterpregnantwomenfallasleep.Propofol30mgwasadministeredi.v.iftheoperationwa
6、sdisturbedbythemovementofpregnantwomen.MAP,HRandSpO2wererecordedbeforeinjection,at2,4minafterinjectionandtheendofoperation.Thetimeofoperation,openingeyes,andleavinghospitalwererecorded.Thedosageofpropofol,anesthesiaeffectrating,incidenceofadversereactions(includinghypoxia,dizzy,nauseaandvom
7、iting)andVASwererecorded.Results：DosageofpropofolandVASwerereducedingroupBcomparedwithgroupP(P<0.05).AnesthesiaeffectratingwasbetteringroupBcomparedwithgroupP(P<0.05).MAPandHRat2,4minafterinjectionwerereducedingroupBcomparedwithgroupP(P<0.05),wh
