临床医学先天性心脏病概论黄国英课件

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1、HUANGGuoying（黄国英）DepartmentofPediatricsFudanUniversityShanghaiMedicalSchoolChildren’sHospitalofFudanUniversityCardiovascularDiseasesinChildren（Conspectus）TheAimofThisClassTounderstandtheclassificationofCHDToknowwelltheembryologicaldevelopmentofheart,causesofCHDanditspathogenesisToknowwelltheapp

2、roachesofevaluationofCHDToknowthecharacteristicsoffetalcirculation&changesafterbirthTohaveageneralideaaboutcardiovasculardiseasesinchildren,andtheprincipleoftreatmentofCHDChildren’sHospitalFoundedin1952ProfessorCHENCuizhenCardiovascularDiseasesinChildrenCongenitalheartdiseaseViralmyocarditisRheum

3、aticheartdiseaseCardiomyopathyKawasakiDiseaseArrhythmiaCongestiveheartfailurePericarditisInfectiveendocarditisEtc….EmbyologicalDevelopmentofHeartFormationofprimitivehearttubeLoopingofprimitivehearttubeFormationofendocardialcushionFormationofinteratrialseptumFormationofinterventricularseptumSeptat

4、ionofaorticandpulmonaryarteriesFormationandLoopingofPrimitiveHeartTubeFormationofEndocardialCushionAVcanalposteriorrightAVorificeanteriorleftAVorificeFormationofEndocardialCushionSeptationofAtriaandVentriclesostiumprimum1＝LA胚胎第3周胚胎第4周胚胎第5-6周胚胎第7-8周2＝LV3＝RA4＝RV5＝septumprimum6＝septumsecundum7＝endoc

5、ardialcushionostiumsecundumforamenovale8,9＝ventricularseptaInterventricularforamenSeptationofAtriaSeptationofVentriclesIVSiscomposedofthreeparts：①muscularseptum②cushioncomponent③A-PseptumcomponentSeptationofGreatArteriesAOPAPAAOPAPAAOAOPAAOPAPAPAPAMalpositionofGreatArteriesTOFTGADORVTaussig-BingE

6、volvementofArterialArchesobsoletesoonafterbirthcarotidarteriessubclavianA.brachiocephalicA.ductusarteriosusbranchesofpulmonaryartery1stpair2ndpair3rdpair4thpair5thpair6thpairFetalCirculation&ChangesafterBirthafterbirthbeforebirthCongenitalHeartDiseasesDefinition：Cardiovascularmalformationspresen

7、tduringembryonicstages（胚胎期发生的心血管畸形）Prevalence：－7~8/1000newborns（reporteddata）－6.87/1000newbornsinShanghai（epidemiologicsurveyduring1989～1991）EtiologicConsiderationsHereditaryfactorsTrisomiesofchromosome21,18,13CATCH22s