fda批准的抗肿瘤药物1949-2003

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1、DrugNameTradeNameIndictionsManufacturerTimechlorambucilLeukeranChronicLymphocyticLeukemia-palliativetherapyGlaxoSmithKline meclorethamine,nitrogenmustardMustargen MerckMar151949leucovorinWellcovorin,LeucovorinLeucovorincalciumisindicatedfrouseincombinationwi

2、th5-fluorouraciltoprolongsurvivalinthepalliativetreatmentofpatientswithadvancedcolorectalcancer.ImmunexCorporationJun201952mercaptopurine,6-MPPurinethol GlaxoSmithKlineSep111953methotrexateMethotrexate LederleLaboratoriesDec071953busulfanoralMyleranChronicMy

3、elogenousLeukemia-palliativetherapyGlaxoSmithKlineJun261954chlorambucilLeukeran GlaxoSmithKlineMar181957thiotepaThioplex ImmunexCorporationMar091959methotrexateMethotrexate LederleLaboratoriesAug101959nandrolonephenpropionateDurabolin-50 OrganonOct301959cycl

4、ophosphamideCytoxan,Neosar Bristol-MyersSquibbNov161959cyclophosphamideCytoxanInjection Bristol-MyersSquibbNov161959DROMOSTANOLONEPROPIONATEDROMOSTANOLONE EliLillyOct261961fluorouracil,5-FUAdrucilprolongsurvivalincombinationwithleucovorinICNPuertoRicoApr2519

5、62UracilMustardUracilMustardCapsules RobertsLabsSep131962vincristineOncovin EliLillyJul101963yearsmortgagehousing;4.mortgageregistrationformalitiesarecompleted.(D)pledge1.borrower(includingthepledgor)between18-65yearsofage,withfullcivilcapacity;2.collateralv

6、incristineOncovin EliLillyJul101963vincristineOncovin EliLillyJul101963vincristineOncovin EliLillyJul101963vincristineOncovin EliLillyJul101963vincristineOncovin EliLillyJul101963vincristineOncovin EliLillyJul101963melphalan,L-PAMAlkeran GlaxoSmithKlineJan17

7、1964dactinomycin,actinomycinDCosmegen MerckFeb041964DROMOSTANOLONEPROPIONATEMASTERONEINJECTION SYNTEXOct081964quinacrineAtabrine AbbottLabsDec071964dactinomycin,actinomycinDCosmegan MerckDec101964vinblastineVelban EliLillyNov051965thioguanine,6-TGThioguanine

8、 GlaxoSmithKlineJan181966pipobromanVercyte AbbottLabsJul011966hydroxyureaHydrea Bristol-MyersSquibbDec071967testolactoneTeslac Bristol-MyersSquibbJun031969cytarabineCytosar-U Pharmacia&UpjohnCom