深部静脉血栓的遗传危险因素（英文）

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1、ToshiyukiMIYATA,PhDNationalCardiovascularCenterResearchInstitute,Osaka,Japanthe19thGreatWallInternationalCongressofCardiology,October24,2008GeneticriskfactorsforvenousthromboembolisminJapaneseAdvancedageisariskforvenousthromboembolism(VTE)AllVTEBlood,11

2、0,3097-3101,2007amongresidentsofOlmstedCounty,Minnesota,from1966to1990PEDVTaloneMaleFemaleIncidenceratesofVTEincreasedramaticallyataboutage55,and,byage80,arenearly1in100peryear,approximately1000-foldhigherthanforthoseaged45oryounger.Riskfactorsforvenous

3、thromboembolismNEnglJMed,358,1037-52,2008AcquiredfactorsReducedmobilityAdvancedageCancerAcutemedicalillnessMajorsurgeryTraumaSpinalcordinjuryPregnancyandpostpartumperiodPolycythemiaveraAntiphospholipidantibodysyndromeOralcontraceptivesHormone-replacemen

4、ttherapyHeparinsChemotherapyObesityCentralvenouscatheterizationImmobilizerorcastHereditaryfactorsAntithrombindeficiencyProteinCdeficiencyProteinSdeficiencyFactorVLeidenProthrombingenemutationThrombo-modulinendotheliumEPCRPCPSprothrombinFVaFXaFVaFVIIIaHS

5、PGthrombinAPCProteinC/proteinSsystemProteoglycansulfatesystemHeparansulfateFViFVIIIiIIaATAnticoagulantSystemsonEndotheliumCaucasianJapaneseFactorVLeidenProthrombinG20210ADeficienciesofproteinC,proteinS,antithrombinLowfrequencyvariationDeficienciesofprot

6、einC,proteinS,antithrombinVeryraremutationGeneticriskfactorsforvenousthromboembolismProteinSK196ETokyoGeneralpopulation,SuitastudyatNCVCVTEpatients:Sub-groupofBloodCoagulationAbnormalityStudyGroupSuita,OsakaNCVC,OsakaUNagoyaUJichiMedUKeioUnivKyotoPrefMe

7、dUAbout170JapaneseVTEpatientsCase-controlstudyforVTEmorethan3,500individualsfromageneralpopulationrandomlyselectedfromSuitacityresidentsKimuraetal.,Blood,2006VTE1392011600.06932903321736390.0502.1790.336ProSerMajorhomoHeteroMinorhomoTotalMAFMajorhomoHet

8、eroMinorhomoTotalMAF2PMajoralleleMinoralleleGeneralpopulation(Suitastudy)152901610.0283501149036500.0200.9870.320AlaThr1461321610.053358566036510.00975.464<0.0001LysGluFXII-4C>T6169301600.4031468168649736510.3673.4020.1834G5GADA