资源描述：
《医学课件淋球菌的免疫逃避》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、更多医学精品 尽在医学吧http://www.docin.com/rayshiuImmuneevasionofNeisseriagonorrhoeae淋球菌的免疫逃避（淋球菌利用（剥削）宿主的先天免疫）TieChen,M.D.ProfessorTongjiHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyVisitingAssociateProfessorIndianaUniversitySchoolofMedicine华中科技大学
2、同济医学院附属同济医院N.gonorrhoeae,(gonococci,GC,thecauseofgonorrhea)奈氏淋球菌GonococciInvadeHostCells淋球菌侵入属主细胞SomeFactsaboutNeisseriagonorrhoeae(gonococci,GC)1.GenitalInfection:gonorrhea2.Cervical-pelvicinflammatorydisease(PID)3.Pharyngeal,RectalInfection,eyeandsystemicspre
3、ad4.Othernotednames:Clap,Flowingseeds,HappydiseaseandMotherofSTD6.Itisanancientdisease.古老的疾病5.78millioncaseseachyear.7.Noanimalmodel没有动物模型8.Doesnotgenerateprotectiveimmuneresponse不产生保护性免疫9.AbilitytofacilitateHIVinfection?能促进HIV的感染GCFormsOpaqueColoniesOpaProtein
4、ExpressionInteractionofNeisseriagonorrhoeaewithHostCells1.Initialadherence2.Tightadherence3.Invasion/uptake4.Transcytosis奈氏淋球菌与宿主细胞的相互作用初期粘附紧密粘附侵袭/吞噬胞吞转运Neisseriagonorrhoeaeinhibitshostresponses.证明CEA(CD66,carcinoembryonicantigen)抗原是奈氏淋球菌的受体R.J.Belland*,T.Chen,
5、J.SwansonandS.H.Fischer.1992.Mol.Microbiol.6:1729-1737.T.Chen,R.Belland,J.Wilson,andJ.Swanson*.1995.J.Exp.Med.182:511-517.T.Chen,J.Swanson,J.Wilson,andR.Belland*.1995.Infect.Immun.63:1790-1795.T.Chen*andE.Gotschlich.1996.Proc.Natl.Acad.Sci.USA.93:14851-14856.T.
6、Chen*,F.Grunert,A.Medina-MarinoandE.C.Gotschlich.1997.J.Exp.Med.185:1557-1564.CEA(CEACAM,CD66,carcinoembryonicantigen)AgServeasReceptorsforOpa+GCCEACAM1,(BGPaCD66a)CEACAM3,(CGM1a,CD66d)MembraneExtracellularCytoplasmicCEACAM6CEACAM8ITAMITIMActivationInhibitionCE
7、A(CD66)抗原是奈氏淋球菌的受体阳阴?BTKT.Chen*,W.Zimmermann,J.Parker,I.Chen,A.MaedaandS.Bolland.2001J.Leuko.Biol.70:335-340.T.Chen*,S.Bolland,I.Chen,J.Parker,M.Pantelic,F.Grunert,andW.Zimmermann.2001.J.Biol.Chem.276:17413-17419.阳性和阴性的信号传递抑制抗体产生PotentialITAMorITIMMotifintheCyt
8、oplasmicDomainOfBGPaandCGM1aImmunoreceptorTyrosine-basedActivation(orInhibition)MotifITAMD/ExxxxxxxD/ExxYxxLxxxxxxxYxxL/IITIMV/IxYxxLBGPaDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEI
