乳腺型肌纤维母细胞瘤_1课件

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1、Mammary-typemyofibroblastoma乳腺型肌纤维母细胞瘤一、Definition定义Abenignmesenchymalneoplasm良性间叶性肿瘤composedofspindle-shapedcellswithfeaturesofmyofibroblasts,由梭形有肌纤维母细胞特征的细胞构成的embeddinastromathatcontainscoarsebandsofhyalinizedcollagen间质内含有玻璃样变的粗大胶原纤维条带andconspicuousmastcells可见大量的肥大细胞andadmixedwithavariablea

2、mountofadiposetissue.并伴有数量不等的脂肪组织。thetumourishistologicallyidentiacaltomyofibroblastomaofbreast.其组织学特点与乳腺的肌纤维母细胞瘤相似。二、Epidemiology流行病学Lesionhaveariseninadultswithanagerangeof35to67years(median55.5years)andamalepredilection(8males,2females).发病年龄见于35-67成年人（平均55.5）男性多见（8例男性，2例女性）Theextrammaryloc

3、ationofsomemyofibroblastomashasonlyrecentlybeendefinedwhen10caseswerereported.乳腺外的肌纤维母细胞瘤直到最近才有10例报告。Therefore,conclusionsrelatedtoepidemiologycouldalterwithincreasedtumourrecognition因此随着对肿瘤认识的增加，流行病学方面也会发生改变。三、sitesofinvolvement受累部位Themostcommonlocationofmammary-typemyofibroblastomaistheingu

4、inal/groinarea.乳腺型肌纤维母细胞瘤最常见于会阴/腹股沟区域。Otherreportedsitesincludeabdominalwall，buttock,backandvaginalwall.其他部位有腹壁，臀部，背部和阴道壁。Lesionsarisemostcommonlyinsubcutaneoustissue.最常见的发病部位是皮下组织。However,caseshavearisendeeptoabdominalwallmuscle，intheposteriorvaginalwallandinaparatesticularlocation.但也可位于腹壁肌肉

5、，阴道后壁和睾丸旁。Thereisanapparentpredilectionformyofibroblastomastoarisealongtheputativeanatomic“milk-line”thatextendsfromaxillatomedialgroin.肌纤维母细胞瘤明显好发于从腋窝至腹股沟中部的“白线”四、Clinicalfeatures临床特点Thetumoursgenerallypresentaseitherpainlessmassesorincidentallesionsthataredetectedduringsurgicalproceduressuc

6、hasinguinalherniarepair.多为无痛性的肿块或由外科进行腹股沟疝修补术时偶然发现隐匿肿块。Occasionallesionsaretenderorpainful偶尔病变区触痛或疼痛。Tumourshavebeendescribedtobepresentforuptoayearbeforeclinicalpresentation.肿瘤就诊前可能已经存在达1年之久Therearenoimagingdata无影像学资料数据五、Aetiology病因学Unknown病因不明Ithasbeenpostulatedthatmyofibroblastomasarisingi

7、nthebreastmayberelatedtoapatient’shormonalstatus,inthatlesionsarerelativelycommoninoldermen.e.g.inthesettingofgynaecomastiaandanti-androgentherapy.据推测发生于乳腺的肌纤维母细胞瘤与患者的激素水平有关.这种情况多见于老年男性。如：男性乳腺发育和抗雄激素治疗的患者。Mammary-typemyofibroblastomaofsofttis