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_between stress sleep and circadian rhythms how do 应力之间的相互作用睡眠和昼夜节律如何课件

_between stress sleep and circadian rhythms how do 应力之间的相互作用睡眠和昼夜节律如何课件

ID：19468684

大小：11.16 MB

页数：34页

时间：2018-10-02

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1、OliviervanReeth,M.D.Ph.D.Centred’EtudesdesRythmesBiologiques,Univ.LibredeBruxellesCentred’EtudesdesTroublesduSommeil,CHIRECDipartimentodiNeurologiaeCentrodiMedicinadelSonno,Univ.Catt.diRomaInteractionsbetweenstress,sleepandcircadianrhythms:fromclinicalsituationstoanimalmodelsPhysiol

2、ogicaladaptationresponsetoenvironmentalchangesTheSTRESSsystem:REACTIVEadaptationtounexpecteddailythreateningenvironmentalchallengesTheCIRCADIANsystem:PREDICTIVEadaptationforexpecteddailyenvironmentalchallengesAtleasttwomajorphysiologicalsystemsareinvolvedintheadaptationoftheorganism

3、toenvironmentalchallengesACTIVATIONOFTHETHEHPAAXISPituitaryHypothalamusGlucocorticodACTH++AdrenalCentresintégrateursCRH/AVPStressAdaptation/Maladaptation·Stressresponse,depression…MaternalCorticosterone·RegulatescerebraldevelopmentinthefetusTHESTRESSREACTIONStimulus-StressorCognitiv

4、eevaluationPhysiologicalresponseNeuroendocrineactivationBehavioralresponseMetabolicresponseHomeostaticstateoftheorganismSuccessfulUnsuccessfulAdaptation-Maladaptation-Diseases:UlcusAmenorrheaAnorexiaSleepdisorders…DepressionTHECIRCADIANTIMINGSYSTEMPVNPosteriorNucleusAnteriorNucleusS

5、CNPVNLateralpreopticNucleusMedianpreopticNucleusExamplesofhumancircadianrhythmsParathyroidHormoneMotoractivityCorebodytemperatureUrinevolumeThyroidStimulatingHormoneCortisolTimeW16248160123453212010037.537.036.536.0WS251516032BehavioralhumancircadianrhythmsRest-activitycycleSleep-Wa

6、keCycleCircadianrhythmsareflattened anddisruptedindepressedpatients     SleepControlDepressed20406080100691215182124369SleepPLASMAMELATONIN(pg/mL)PLASMACORTISOL(ng/mL)Sleep2070120170220691215182124369BODYTEMPERATURE(°C)791113151719212379111353137.237.036.836.636.436.236.

7、0ClockTimeInteractionsStress-CircadianRhythmsinHumansThecortisolresponsetoawakeninginrelationtodifferentchallengetestsanda12-hourcortisolrhythm.Schmidt-ReinwaldAetal.LifeScience,1999.Lowdosesofmelatoninanddiurnaleffectsonthermoregulationandtolerancetouncompensableheatstress.McLellan

8、T,J.Appl.Physiol.,1

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