_papillomavirus人乳头瘤病毒（ppt74）课件

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1、HumanPapillomavirus(HPV)GenitalWartsHumanPapillomavirus(commonlycalledGenitalWarts)HumanPapillomavirus(HPV)isavirusthatcancausevariousdiseasestatesincluding“genital”or“venereal”wartsPapillomavirusesareacomplexgroupofDNAtumorviruses.Theycancausebenigngrowths(papillomas),cancers,ormorec

2、ommonly,transientinfectionsHPVinfectioniscausallyassociatedwithcervicalcancer;othergenitalcancersincludinganal,penile,vulvar,andvaginalcancersmayhaveHPVasco-factorHPVPrevalenceMostcommonSTDYearlyincidenceof6.2million20millioncurrentlyinfected80millioninfectedatleastoncebetweentheagesof

3、15-49Anestimated9.2millionsexuallyactiveadolescentsandyoungadults15-24yearsofageareinfectedwithgenitalHPVAnestimated5%-30%ofpeopleinfectedwithgenitalHPVareinfectedwithmultipletypesofthevirus316,000initialvisitstophysicians’offices(2004)-genitalwartdiagnosisGENITALHPVINFECTION1%1.4MILLI

4、ONVISIBLEWARTS4%5MILLIONSubclinical(Colposcopy)10%14MILLIONSubclinical(DNAtesting)60%81MILLIONPriorinfection(+antibodies)25%34MILLIONNoprior/currentinfectionEpidemiologyofHPVandCervicalCancerOver99%ofcervicalcancershaveHPVDNAdetectedwithinthetumor70%ofcervicalcanceriscausedbyoneoftwot

5、ypesofHPV,16or18ThequadrivalentHPVvaccineprotectsagainstTypes6,11,16and18RiskFactorsforAcquiringaGenitalHPVInfectionYoungage(lessthan25years)MultiplesexpartnersEarlyageatfirstintercourse(16yearsoryounger)Malepartnerhas(orhashad)multiplesexpartnersHPVTransmissionDirectskin-to-skinconta

6、ctUsually,butnotalwayssexualcontactInfectedbirthcanalFomites(veryrare)Frictionandabrasionarekeyfactors.Difficulttodeterminehowandwhereinfectionoccurredduetopoorstandardizedtestsandvariablelatencyperiods.Whataboutoralsex?Itcanoccurinthemouth,throatorrespiratorytractItisrelativelyuncommo

7、nItappearstobeaninefficientmodefortransmissionHPVIncubationAverageincubationis3weeksto1yearPossiblyyearsbeforeappearanceofwartsorcervicalabnormalitiesSomewillbetransientandmayneverbedetectedCommonSymptomsofGenitalWartsinMales&FemalesThesymptomsmayincludesingleormultiplefleshygrowthsa