甲壳素类神经导管修复周围神经的研究与进展

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1、万方数据中国组织工程研究与临床康复第f3眷第47期2009—11—19出版JournalofOlinicalRehabilitativeTissueEngmeeringResearchNovember19，2009VoL13,No．47综述甲壳素类神经导管修复周围神经的研究与进展★张万里1，王伟2ProgressofchitinnerveconduitinperipheralnerverepairZhangWan～li，WangWei2Abstract0BJECTlVE：Tosummarizetheprogressonthebiomaterialsofchit

2、innerveconduittorepairperipheralnerveinjuryInrecentyears．DATASOURCES：Acomputer-basedonlinesearchofliteraturesrelatedtotheapplicationofthebiomaterialsofnerveconduitonperipheralnerveinjurywasperformedinMedlineandSpringerlinkbyusingthekeywordsof。nerveconduit。peripheralnerveinjury”betwe

3、enJanuary2000andAugust2009andthelanguagewaslimitedtoEnglish．Meanwhile．wesearchedChinaPeriodicalsFull-te)(tDatabaseandWeipudatabasefortherelatedChinesearticlespublishedbetweenJanuary2000andAugust2009withthesamekeywordsjnChinese．STUDYSELECTl0N：Inclusivecriteria：Researchesaboutthenon—b

4、iodegradablematerials．biodegradablematerialsandbiologicalderivativematerialsthatwererelatedtotheperipheralnerveinjurywereincluded．Exclusivecriteria：Theirrelevantandrepeatedarticleswereexcluded．MAlNOUTCOMEMEASURES：Nervetissueengineering，chitinnerveconduit，andpreparationofnerveconduit

5、．RESULTS：WiththeprogressofmedicaImaterials．theneuraltubeofnatureIorsyntheticmaterialsusedtobridgedefectoftheneuralinnervetissueengineeringscaffoldmaterialwithaguideandtopromotenerveregeneration．Inthebiodegradablematerial，chitinneuraltubecouldbedegradedwithinareasonableperiodoftime，b

6、iologicalcontrolcompatibility，performancedegradation，mechanicalpropertiesandporosity．Andinthestructureoftheconduit，combinedotherbiodegradablematerials。su内cemodification，addingseedcellsandnervegrowthfactor，andotheraspectsoftheexperimentalstudywereinvestigated．Changingthespatialstruct

7、ureofrenewableandmicro-environmentaimedtospeeduptherateofnervegrowth，andpromotetheresumptionofthegoodnervefunction．Andmaterial’ssurfacehadtobemodifiedandimprovedforconduittoadaptnerveduringthenerveregeneration．CONCLUSl0N：Withthecontinueddevelopmentofbiotechniqueandcross-correlationt

8、echnique，thebiomate