核黄素对心绞痛治疗作用的临床研究

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1、维普资讯http://www.cqvip.com·174·高血压杂志ChineseJournalofHypertension1998Sept6(2)调节障碍，导致高血压病的发生和发展。ofheartperiodvarisbititytwoweeksa~teraeut~myocardialiniarctionAmJCardio]1992；69：891REFERENCES4Guz~ttiS，PiccaJugaE，CasatiR，etat．Sympatheticpredomioaneeinessendalhypertension{Astudye

2、mptoyingspectra]anatysJsof1SwislockiA．Insulinresistanceandhypertension．AmJMedheartratevariabilityJttypertens1988；6：711199O；300：1045DcfronzoRAInsulinresistance：AmuLti]aeedsyndromeresponsi-2SundeepMInsutiaresistanceinsystemichypertension}pharma—bteforNIDDM，obesity，hypertens

3、ion，dys]ipidemia—andeotherapeuticimptications．JCLinPharmacol1995；35：943ather~c[erotiecardvasculardisease．Eh'abe盯Care1991‘l4：1733ThomasJ．Corre[ationamongtimeandfrequencydomainmeasuresn一b核黄素对心绞痛治疗作用的临床研究k,／欠{午。亳堡兰周志泳扬会杰(皖南医学院心血管功能研究所，芜湖241001)TheTherapeuticEfficacyofRibofla

4、vinonAnginaPectorisJinMing，ZuoBaohua，ZhouZhiyong，YangHuijie(InstituteofCardiovascularFunctionResearch，WannanMedicalCollage，WuHu)AI~STRACTAimThetherapeutieefficacyofriboflavin(RBF)onanginawasevaluated．Methods78casesofanginaweredividedintoBgroup(一28，RBF75mg·d一×30，po)．GroupI

5、(n一22，isosorbidedinitrate15mg·d×30，po)andCgroup(=28，placebofor3Odays)．EKG、plateletaggregationinbloodandserummalondiadehyde(MDA)contentwereexaminedbeforeandafterdrug．TheclinieaImanifestationsofanginawererecordedbeforeandaftertreatmenttwoweeksorfourweeks．ResultsThetotaleffe

6、ctiverateofEKGandtherapeuticeffectofanginawassignificantlyhigherinBgroupthanthatinCgroup(P<0．O1．P<001，respectively．)Butnosignificantdiffer-encewasfoundbetweenBandIgroup．ConclusionRiboflavinisaneffectivedrugforanginaandit'smechanismmayberelatedtoantiplateletaggregationandi

7、nhibitinglipidperoxidat[oninpatientwithangina．KEYWORDSriboflavinfanginafisosorbidedinitrate目的观察桉黄素对心绞痛的临床疗效。方法78饲劳力性心绞痛患者随机分成B组(一28，核黄素75mg·d～，po)I组(一22，硝酸异山梨(醇)酯15mg-d～，po)和C组(一28，安慰剂，po)，各组均连续服药4w。用药前后检测静息心电图(EKG)、血小板聚集性(PAG)和血清丙二醛(MDA)含量，并于用药前用药第2W、用药第4W末记录心绞痛症状(醇)酯相比无

8、明显差异，但显著高于C组(P<0．01．P<0．制血小板聚集和抗脂质过氧化作用有关。关键词近年来研究发现摄人大量维生素可降低脑卒中、探讨其可能的作用机制。急性心肌梗塞和猝死等心血管意外的发生率