咖啡酸苯乙酯对大肠癌细胞抑制作用及对βcatenin通路相关基因的影响

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1、第三军医大学博士学位论文咖啡酸苯乙酯对大肠癌细胞抑制作用及对β-catenin通路相关基因的影响姓名：何渝军申请学位级别：博士专业：外科学（普外）指导教师：刘宝华20040501第三军医大学博士学位论文英文缩写一览表英文缩写英文全称中文全称ACFaberrantcryptfoci畸形腺窝灶AOMazoxymethane氧化偶氮甲烷APCadenomatouspolyposiscoli结肠腺瘤性息肉病bpbasepairs碱基对CAPEcaffeicacidphenethylester咖啡酸苯乙酯COX-2cyclooxygena

2、se-2环氧化酶-2CRCcolorectalcancer大肠癌DABdiaminobenzidine二氨基联苯胺DEPCdiethylpyrocarbonate焦碳酸二乙酯DMSOdimethylsulfoxide二甲基亚砜EBethidiumbromide溴化已啶EDTAethylenediaminetetraaceticacid乙二胺四乙酸FCMflowcytometry流式细胞术GAPDHglyceroldehyde3-phosphatedehydrogenase三磷酸甘油醛脱氢酶GJICgapjunctionalint

3、ercellularcommunication细胞间缝隙连接信号GSK-3glycogensynthasekinase-3糖原合成酶激酶-3HMGhighmobilitygroup高迁移区IC5050inhibitoryconcentration半数抑制药物浓度KDkilo-dillton千道尔顿Leflymphoidenhancerfactor淋巴样增强因子MCRmutationclusterregion突变密集区MDRmultidrugresistance-1多耐药基因MMPmatrixmetalloproteinase基质

4、金属蛋白酶MTT3-(4,5-dimethyl-2-thiazoly)2,5-diphenyl-2H-四甲基偶氮唑蓝tetrazoliumbromidemRNAmessengerRNA信使RNANESnuclearexportsignals核输出信号1第三军医大学博士学位论文NF-BnuclearfactorkappaB核因子-BIODintegralopticaldensity积分光密度PBSphosphatebuffersaline磷酸缓冲液PCRpolymerasechainreaction聚合酶链式反应PIpropdiu

5、miodide碘化丙啶PPARperoxisomeproliferator-activatedreceptor过氧化物酶体增殖体激活受体PSphosphatidylerine磷脂酰丝氨酸RT-PCRreversetranscriptase-polymerasechain逆转录聚合酶链反应reactionSDSsodiumdodecylsulphate十二烷基磺酸钠TBETris/borate/EDTA(buffer)Tris/硼酸/EDTA缓冲液Tcf-4Tcellfactor-4T细胞因子-4Tristris(hydroxym

6、ethyl)aminomethane三羟基氨基甲烷uPAurokinaseplasminogenactivator尿激酶纤溶酶原激活物VEGFvascularendothelialgrowthfactor血管内皮生长因子2第三军医大学博士学位论文Theantiproliferationeffectofcaffeicacidphenethylesteronhumancolorectalcancercelllinesanditsinfluenceonthemutualitycomponentof-catenincorrelation

7、pathwayAbstractColorectalcancer(CRC)isacommonkindofmalignantcancer.Inrecentyears,somestudieshaveindicatedthatinmostofCRC,therehasbeenanactivatingmutationofthe-catenincorrelationsignalingpathway.The-catenincorrelationsignalingpathwayplayscriticalrolesincellproliferati

8、onanddifferentiationinmanystagesofdevelopment,andthe-cateninisthecentercomponentinthepathway.Aberrant-cateninsignalingpathway,which