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1、中国组织工程研究与临床康复第15卷第11期2011–03–12出版JournalofClinicalRehabilitativeTissueEngineeringResearchMarch12,2011Vol.15,No.11椎间注射转化生长因子β1对兔退变腰椎间盘蛋白多糖表达的影响★12111吴彬，张辉，王海滨，贾存岭，赵益峰Effectsofintervertebralinjectionoftransforminggrowthfactorbeta1onproteoglycanexpressioninrab
2、bitdegeneratedlumbardiscs12111WuBin,ZhangHui,WangHai-bin,JiaCun-ling,ZhaoYi-fengAbstract1BACKGROUND:Invitroexperimentshaveconfirmedthattransforminggrowthfactor-β1(TGF-β1)canpromoteproteoglycanDepartmentofsynthesisanddelayintervertebraldiscdegeneration,butit
3、sinvivoroleremainsunclear.Orthopedics,AffiliatedHospitalofOBJECTIVE:TostudytheeffectoflocalutilizationofTGF-β1onproteoglycanexpressioninrabbitdegeneratedlumbardiscs.JiningMedicalMETHODS:Thirty-sixNewZealandwhiterabbitsweredividedintotwogroupsrandomly,with6i
4、ncontrolgroupand30inmodelCollege,Jininggroup.Thelumbarstructurewasdestroyedpartlyinthemodelgroup.After12weeks,theintervertebraldiscdegenerationwas272000,ShandongtestifiedbyX-rayinmodelgroup.Sixrabbitschosenrandomlyfromthemodelgroupandallrabbitsinthecontrolg
5、roupwereProvince,China;2DepartmentofkilledandtheorganizationsoftheintervertebraldiscsofL4-5wereharvested.Meanwhile,therestrabbitsinmodelgroupwereOrthopedics,dividedintotwogroupsrandomly,whichwasinjectedwithTGF-β1saline.Therabbitswerekilledby2and4weeksafteri
6、njection.AffiliatedHospitalofThecontentsofproteoglycaninnucleuspulposusweretestedbyphloroglucinolmethod.TaishanMedicalRESULTSANDCONCLUSION:Thecontentofproteoglycaninthenucleuspulposuswasobviouslydecreasedat12weeksafterCollege,Taian271000,Shandongmodelprepar
7、ation(P<0.01).AfterTGF-β1injection,thecontentofproteoglycanwasnotablyincreased(P<0.01).ItisProvince,ChinasuggestedthatintervertebralinjectionofTGF-β1torabbitcandelayintervertebraldiscdegenerationandenhancethesynthesisofproteoglycaninnucleuspulposus.WuBin★,M
8、aster,Attendingphysician,DepartmentofWuB,ZhangH,WangHB,JiaCL,ZhaoYF.Effectsofintervertebralinjectionoftransforminggrowthfactorbeta1onOrthopedics,proteoglycanexpressioninrabbitdegeneratedlumbardiscs.Zho
