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时间:2018-09-15
《软骨细胞、胶原纤维及蛋白多糖在家兔不稳定膝关节软骨退变进程中的变化》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、万方数据中国组织工程研究与临床康复彳争74卷第7勇亨2010—02—12出版Jouma
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3、InicalRehab¨naliveTissueEngineenngResearchFebruary12.2010v01.14.No.7软骨细胞、胶原纤维及蛋白多糖在家兔不稳定膝关节软骨退变进程中的变化★徐斌,刘涛,徐洪港ChangesofchondrOcytes,co¨agen竹bersandproteOglycandur-ngarticuIarcart¨agedegenerationin怕bbitswithkneejointinstab川tyXuBin.Liu。raO,XuHong-ga
4、ngDeOa巾nentofo^hO∞edicsSurgemFi佑tA删iaIedH08DItaIofAnhuiMedj∞IUnive俜i虬Hefej230022.AnhuiProvin∞.ChinaXuB.n★.MaslenChiefphysician,Master’ssUDervisOLDeDanmentofO^hODaedicsSurge啊Fi嘣A币晒tedH08D蛔lofAnhuiMedi∞lUn№懵ItMHefei230022.AnhuiPravin∞.Chinax}nyon92007@126.cOmRe∞i"d:2009-08-09A∞emed:2009·09_31安徽医科大
5、学第一附属医院骨科,安徽省合肥市230022徐斌★,男,1964年生,安徽省桐城县人,汉族,1994年安徽医科大学毕业,硕士,主任医师,硕士生导师,主要从事关节外科研究。xinyon92007@126.com中图分类号:R318文献标识码:A文章编号:1673-8225(2010)07·01166·04收稿日期:2009-08-09修回日期:2009_09.31(20090709010^~‘z)1166AbStraCtBACKGROUND:KneeiointtraumaresuItsinkneeinstab.¨tyandmovementtrackchanges,whichIeadtot
6、hedearadationofarticuIar∞n.Iages.ThemaincomponentofanIcuIarcanIlages,suchaschondrocytes,co¨agenandproteogIy∞n,a怕aIsochangeduringthispmcess.OBJECTlVE:TO∞mparethecOntentchangesofco¨agen,proteOglycanandtheapOptosisofchondrocytesOntwOmOdeIgroUpsofkneejoinlinstabiIity'additiona¨y,toinVes“gatetheoccur
7、rencemechanIsmofearlyanIcuIarca川lageschangesinrabbitswithkneejointInstab¨ity.METHoDS:AlofaOf50whjterabbjfSwe怕阳ndOmJyd}vjdedjncoanle—OrcrucjateJjgamenctranse_c廿Ongroup'medjaJcoIlaleraIIigamentI旧nsectiOn+me九iscectOmygroupandnOrmaIcontrolgroup.Thespecimenswerehan,estedatweeks1,2,3,4。and5afterOpe阳“O
8、n.TheOsteOcan.IaginOussectIOnOfthemediaIfemurcondyIeswereObservedbygrossObservatiOn,histolOgIcalexamInatiOn,andMarkins∞怕s.ThecontentsOfproteoglycanand∞¨agenf№erwereaIsOmeasu旧d.RESUL-TSANDCONCLUSlON:Chondrocytesapoptosiswe怕foundwithcertaindegreesaIdi仟e怕ntstagesofkneejointinstabⅢtymodeIs.TheMankln
9、sco怕oftheanteriorcruciateIigamentt阳nsectiongroupwasg怕aterthanthemediaI∞¨ateraI¨gamentt阳nsection+meniscectomygroupateachtimepointexceptthe1吼week(P《0.05),whichwasnotablygreaterinthe5mweek.Atweeks3and4afterope怕tion。thechondroc”
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