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时间:2018-09-13
《大豆异黄酮降血脂作用的研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、维普资讯http://www.cqvip.com5282DD6.Vo1.27,No.10※营养卫生大豆异黄酮降血脂作用的研究李国莉,赵伟明,杨建军,刘贺荣,任彬彬,赵皴,李蕾,康志东(宁夏医学院,宁夏银川750004)摘要:目的:观察大豆异黄酮对高脂血症大鼠血脂的影响。方法:选择成年雌性SD大鼠50只,体重280~320g,随机分为四组:空白对照组:喂饲基础饲料;高脂模型组:喂饲高脂饲料;其余2组分别喂饲添加300、600mg/kg大豆异黄酮的高脂饲料。实验第6周末,空腹12h,5%戊巴比妥钠麻醉后,心脏取血及制备10%肝组织匀浆,测定血清总胆固
2、醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL.C)、低密度脂蛋白(LDL.C)、脂蛋白脂酶(LPL)、肝脂酶(HL)等指标。结果:与高脂组比较,sI剂量组大鼠肝脏中的TC、TG、LDL.C显著降低(P<0.01),HDL.C显著增高(p<0.05),LPL活性显著增强(p<0.05)。结论:大豆异黄酮具有明显的降血脂作用。关键词:大豆异黄酮;血脂;脂蛋白脂酶;肝脂酶EfectsofSoyIsoflavonesonHyperlipidemiaRatsLIGuo—li,ZHAOWei—ming,YANGJian-jun,LIUHe—rong,R
3、INBin—bin,ZHAOYi,LILei,KANGZhi—dong(NingxiaMedicalCollege,Yinchuan750004,China)Abstract:Objective:TostudytheinfluenceofsoyisoflavonesonserumlipidlevelinHyperlipidemiarats.Methods:50SDfemaleratswererandomlydividedin4groups:normaldietcontrol,bd【ghfatdiet,lowdoseSI(300mg/kgbw)+h
4、ighfatdiet,andhighdoseSI(600mg/kgbw)+highfatdiet;ratsofnormaldietcontrolwerefedwithnormaldiet,andratsoftheremaindergroupswerefedwithhighfatdiet.After6weeks,ratswerekilledandhavedetectedserumlipidlevelandactivityofLPLandHLinblood.Results:ComparedwiththegroupofSIdiet,theTC,TG,L
5、DL—Clevelsofthegroupofhighfatdietweresignificantlyhigher,theHDL—Clevelweresignificantlylower,theactivityofLPLinserumincreasedobviously.Conclusion:TheseresultssuggestedthatsoyIsoflavonescandecreasethesel'uR1lipidlevelobviously.Keywords:soyisoflavones;serumlipid:LPL;HL中图分类号:$52
6、文献标识码:A文章编号:1002.6630(2006)10.0528—04收稿日期:2006.07.29基金项目:宁夏回族自治区卫生厅资助项目(W2004012)作者简介:李国莉(1954.),女,副教授,主要从事保健食品的研究。Lett。200l,174:73-81.indiabetes[J].JSurgRes,1997,70:l19—123.[4]JiYL,Woo—IH,SeungTL.AntioxidantandanticanceractivitiesofBodenG,ChenX.1qbalN.Acuteloweringofplasmafa
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8、trandA,eta1.ModulationofPlatycodongrandiflommelicitsthereleaseofnitr
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