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1、AIDS(AcquiredImmuneDeficiencySyndrome)Dept.OfInfectiousDiseaseXiaoguangDouDefinitionSever&oftenfatalchronicdiseaseHIV(HumanimmunodeficiencyVirus)CD4+TlymphocyteOpportunisticinfection&malignanttumorSexualcontact&injectiontransmissionEtiologyCausativeorga
2、nism:HIVHIV-1&HIV-2Single-strandRNA,retroviridae,genome9.7kb3structuralgeneenvgene:envelopePro.--gp120,gp41gaggene:corepro.--P24&mediumPpolgene:polymerase,retrotranscriptase.genehomologousofHIV-240-50%comparingwithHIV-1EtiologyResistance:sensitivetoheat
3、:56oC30min>25%alcoholIsolation:bloodcell,plasma,lymphnodes,semen,saliva,tears,breastmilk.Targetcell:CD4+T,M,Bcell,NervecellEpidemiologySourceofinfection:patientsasymptomaticcarriersRouteoftransmission:sexualcontacttransmission:homosexualorbisexual:Weste
4、rnworldheterosexual:Africainjectiontransmission:intravenousdrugabusersbloodoritscomponentstransfusionEpidemiologyRouteoftransmission:verticalspread:placenta:frommothertoinfantbreastmilkotherroute:organtransplants,artificialinseminationneedle-stick,hospi
5、talstaffEpidemiologySusceptibilityofpopulation:at-riskgroupsmalehomosexualorbisexualintravenousdrugabusersbloodtransfusion>40yrs.malePathogenesisHIVisacytotoxicvirusHIVinterferwithCD4function&reduceitsnumberClinicalmanifestationIncubationperiod:2to10yrs
6、.Firstperiod-IllnessofinfectionSymptoms:fever,headache,anorexia,nausea,enlargementoflymphnodesHIV+,P24Ag+,CD4/CD8invertedratioLast2weeksClinicalmanifestationSecondperiod-AsymptomaticcontactInitialHIVinf.orafterillnessofinf.NosymptomsHIV+,Anti-coreAg+,an
7、ti-envelopeAg+Last2to10yrs.ClinicalmanifestationThirdperiod-PGL(PersistentGeneralizedLymphoadenophathy)Enlargementoflymphnodesoutsidetheinguinalareamorethan2areasmorethat3monthsClinicalmanifestationFourthperiod-ManifestAIDSARC(AIDS-relatedcomplex):fever
8、,lossofweight,anorexia,diarrheapluPGLnervoussystemsymptoms:headach,convulsion,paralysis,progressdementiaRareopportunisticinfectionUnusualmalignanttumorsPneumoniaClinicalmanifestationClinicalClassification:ClassA:illnessofinfectio
