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时间:2017-11-13
《医药学临床医学毕业论文 柯萨奇病毒感染临床表现的多样性》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、湖南师范大学本科毕业论文考籍号:XXXXXXXXX姓名:XXX专业:医药学临床医学论文题目:柯萨奇病毒感染临床表现的多样性指导老师:XXX二〇一一年十二月十日【摘要】目的探讨小儿柯萨奇病毒感染的临床特点。方法回顾分析98例柯萨奇病毒感染的临床表现及实验室资料。结果柯萨奇病毒感染夏秋季节发病率高,最常见的症状是发热(90.8%)、咳嗽(52.0%)、腹泻(29.6%)、咽痛(22.4%),其次是胸闷心悸(13.3%)、一过性瘫痪(8.2%)、头痛、呕吐(7.1%)。最常见的体征是肝、脾、淋巴结肿大(分别为31.6%、2
2、7.6%、17.3%),其次是皮疹(12.2%)、肺部干湿口罗音(11.2%)、咽部疱疹(10.2%)、口腔黏膜溃疡(7.1%)。实验室检查心肌酶升高最常见(CB-MB升高占27.6%,LDH升高占52%),其次是肝功能异常(ALT升高占16.3%,胆汁酸升高占22.4%)及末梢血发现异形淋巴细胞(19.4%),另外粒细胞减少(11.2%),尿检异常(14.3%)。19.4%有多器官多系统损害。结论柯萨奇病毒感染临床表现复杂多样,除表现为较典型综合征外,亦是类传染性单核细胞增多症、小儿肺炎的重要病原,免疫性疾病的始动
3、环节,常见多器官多系统损害。需与E-B病毒(EBV)、巨细胞病毒(CMV)、支原体(MP)感染及败血症相鉴别。X【关键词】柯萨奇病毒;多器官多系统损害;小儿【Abstract】ObjectiveToinvestigatetheclinicalfeaturesofCoxsackievirusinfectioninchildren.MethodsRetrospectivecohortstudywasdonetoinvestigateclinicalmanifestationsandlaboratoryfindingsof
4、Coxsackievirusin98children.ResultsTheincidenceofCox-sackievirusinfectionwashighinthesummerandfall.Feverwaspresentin90.8%ofthecases.Coughwasfoundin52%,diarrheain29.6%,sorethroatin22.4%,oppressivesensationoverthechestandpalpitationin13.3%,transientparalysisin8.2%
5、,headacheandvomitingin7.1%.Signsofhepatomegaly,splenomegalyandenlargedlymphnodeswereshowedin31.6%,27.6%,17.3%ofthecasesrespectively,rashesin12.2%,dryandwetraleofthelungin11.2%,blebofthroatin10.2%,oralulcerin7.1%.Labo-ratorytestsshowedthatCK-MBandLDHwereelevated
6、in27.6%and52%,andALTandbileacidwereelevatedin16.3%and22.4%.Therewereatypicallymphocytesofdistalbloodin19.4%,leucopeniain11.2%andabnormalroutineurinein14.3%.Testssuggestedmultipleorgansandmultiplesystemsdisfunctionin19.4%.ConclusionsTherearevariousclinicalmanife
7、stationsofCoxsack-ievirusinfection.Besidestypicalform,itwasanimportantcauseofinfectiousmononucleosis-likesyndromeandchildren’spneumonia.It’sapossibletriggerofimmunediseases.Multipleorgansandmultiplesystemsdisfunctionarecommon.It’snecessarytodifferentiatewithEps
8、tein-Barrvirus(EBV),cytomegalovirus(CMV),mycoplasma(MP)andsepticaemia.【Keywords】Coxsackievirus;Multipleorgansandmultiplesystemsdisfunction;Youngchild柯萨奇病毒(Coxsackievirus)属于肠
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