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时间:2018-09-02
《骨肿瘤病理活检有效性的影响因素分析.doc》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、骨肿瘤病理活检有效性的影响因素分析作者:姬涛,郭卫,沈丹华,汤小东,杨毅,董森【摘要】[目的]评价骨骼系统病变病理活检的有效性;明确影响活检准确率的独立危险因素,并分析该因素对穿刺活检后导致切开活检几率的影响。[方法]回顾性分析2003年6月~2006年10月间共206例骨破坏病例,所有病例均进行芯针穿刺或切开活检。比较活检病理结果与术后病理结果是否一致,将病理活检结果分为正确、无诊断和错误3种。将结果正确的活检定义为有效活检;将结果错误和无诊断的活检定义为无效活检。分析下列因素对活检有效性的影响:活检方式、病变位置
2、、黏液成分、病变种类,明确病理活检有效性的独立危险因素;同时分析其对阴性穿刺结果导致切开活检发生率的影响。[结果]206例患者中,147例(71.4%)患者行芯针穿刺活检,47例(22.8%)行切开活检,12例(5.8%)患者进行芯针穿刺后,再次进行切开活检。176例(85.4%)活检结果正确,19例(9.2%)无诊断,11例(5.3%)活检结果错误。Logistic多因素回归分析提示病变含有黏液成分是影响活检正确率的独立危险因素(P=0.02)。[结论]大部分骨骼系统病变通过芯针穿刺活检或切开活检可以明确诊断。病变
3、内有黏液成分会降低活检诊断的正确率;没有单一因素增加切开活检几率。骨骼系统病变的正确诊断仍需依靠临床、病理及影像三结合的模式。【关键词】骨肿瘤;病理活检;有效性Abstract:[Objective]Toevaluatetheeffectivenessofbiopsyofbonelesions.Thefactorsthatmighteffectontheclinicalutilitywereanalyzedinordertofindouttheindependentfactorforclinicaleffective
4、ness.Alsoweevaluatedtheeffectsofthesefactorsontheopenbiopsywithneedlebiopsypreviouslydone.[Method]Weretrospectivelyreviewed206casesperformedatourinstitutebetweenJune2003andOct2006,includingpercutaneouscoreneedlebiopsyoropenbiopsy.Thebiopsyresultwasclassifiedas
5、correct,nondiagnostic,orincorrect.Thebiopsyresultswereconsideredclinicalusefuliftheywerecorrectandnotusefuliftheywerenondiagnosticorincorrect.Weidentifiedtheindependentriskfactorbyanalyzingwhetherthecharacteristicsincludingbiopsymethods,lesionposition,myxoid,le
6、siontypereducedtheeffectontheclinicalutilityandincreasedtheprobabilityofproceedingtosubsequentopenbiopsy.[Result]In206patients,onehundredandfortysevencases(71.4%)underwentcoreneedlebiopsy.Fortysevencases(22.8%)underwentopenbiopsyandtwelvecases(5.8%)hadopenbi
7、opsywithneedlebiopsyfirst.Onehundredandseventysixcases(85.4%)patientshadclinicalusefulresults.Eighteencases(8.7%)werenondiagnostic,andtwelvecases(5.8%)wereincorrect.Myxoidhistologywasidentifiedofindependentriskfactor6ontheclinicalutilitybylogisticregression(P=
8、0.02).[Conclusion]Mostcasesofbonelesionscanbediagnosedbycoreneedlebiopsyoropenbiopsy.Themyxoidhistologyisassociatedwithdecreaseclinicalaccuracy;Nosinglecharacteristiccausei
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