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1、吗啡对垂体后叶素致兔心肌损伤的影响【摘要】目的观察吗啡预处理垂体后叶素引起的兔心肌损伤后血压、心电图和血清心肌肌钙蛋白I(cTn-I)的含量变化，并观察心肌病理切片，探讨吗啡对受损心肌预处理的影响。方法将成年中国白兔24只随机分为三组，对照假手术组(A组)，手术模型完成稳定45min后予0.9%生理盐水0.2～0.3mL/kg，30s静脉注射完毕；药物损伤心肌组(B组)，45min后予垂体后叶素(2.5U/kg)0.2～0.3mL/kg，30s注射完毕；吗啡预处理组(C组)，予吗啡0.65mg/kg静脉推注，45min后予垂
2、体后叶素(2.5U/kg)0.2～0.3mL/kg，30s注射完毕，记录给药前后平均动脉压(MAP)、中心静脉压(CVP)、HR及T波变化；测定血清cTn-I含量；观察给药48h后白兔心肌组织的变化。结果与A组比较，B组MAP、CVP、T波明显升高(P＜0.01)，HR明显下降(P＜0.01)；与B组相比，C组MAP、CVP、T波明显下降(P＜0.01)，T波B、C组明显高于A组(P＜0.01)。血清cTn-I水平A、C组低于B组(P＜0.01)。结论吗啡预处理对垂体后叶素所致的兔心肌损伤有保护作用。【关键词】心肌损伤；吗啡
3、；肌钙蛋白I；双抗夹心免疫吸附法；兔 Abstract:ObjectiveToobservethechangeofbloodpressure,electrocardipgramandTroponinIaftermorphinepretreatmentonacutemyoardialinfarctioninducedbypituitrininrabbits,andtocomparethemwiththechangeofpathostaining,andtoexploretheeffectofmorphinepretreatm
4、entonacutemyocardialischemicinjury.MethodsTwenty-fourrabbitsweredividedrandomlyintothreegroups:controlgroup(GroupA),pituitringroup(GroupB)andmorphinepretreatmentgroup(GroupC).TheinformationincludedMAP、CVP、HRandTwavewereobservedandrecordedatdifferenttimepoints.Itwas
5、dividedintotwoobservingphrasesof24h,48handdeterminedthecontentsofbloodserumcTn-Iandcaridiacpathostainof48h.Results(1)Changesinmyocardiacmechanics:myocardiacmechanicshadadynamicchangeafterinjectionofpituitrin2.5U/kgweight.parametersbetweenandwithingroupsthroughoutth
6、eexperimentalperiodexceptischemiagroup,whichhadasignificantlreductioninHRandasignificantincreaseinMAP,CVPandTwave.Comaredwithothergroups.GroupCcomparedwithGroupA,MAPandCVPateachtimepointtherewasnosignificantstatisticaldifference,HR(1min)decreased(P＜0.05),Twaveincre
7、ased(P＜0.01).ComparedBgroupwithgroupA,MAP(1min)significantlyincreased(P＜0.01),CVPsignificantlyincreasedfrom15secto5min(P＜0.01),HRsignificantlyloweredin15secto10min(P＜0.01),Twavesignificantlyincreased(P＜0.01).ComparedGroupBwithCgroup,HRsignificantlydecreasedatthepoi
8、ntoffrom30secto2min(P＜0.01),MAP,CVPandTwavewasnosignificantstatisticaldifferenceatdiffernettimepoints.(2)BloodserumcTn-Ishowedsignificantdifferen
