性激素通过il-1_il-1r通路促进原发性肝癌的机制的研究性激素通过il-1_il-1r通路促进原发性肝癌的机制的研究

《性激素通过il-1_il-1r通路促进原发性肝癌的机制的研究性激素通过il-1_il-1r通路促进原发性肝癌的机制的研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、修改意见：性激素通过IL-1/IL-1R通路促进原发性肝癌的机制的研究[摘要]目的探讨雌激素E2(Estradiol，E2)是否对原发性肝癌的发生发展有促进作用，以及该作用机制是否通过白细胞介素-1(Interleukin-1，IL-1)/白细胞介素-1受体（Interleukin-1receptor，IL-1R）通路。方法选取我院2013年1月至2014年6月接收的原发性肝癌男性患者作为观察组，选取同期接收的非原发性肝癌患者作为正常对照组，分别采用ELISA法检测两组患者血清中的E2、IL-1β和VEGF浓度，采用Westernblot法检测两组肝肿瘤

2、组织和正常肝组织中E2R和IL-1βR蛋白表达水平。结果观察组患者血清中E2、IL-1β和血管内皮生长因子(VascularEndothelialGrowthFactor，VEGF)浓度显著性高于正常对照组，且两组间比较具有显著性差异（P<0.01）；观察组肿瘤组织中E2R和IL-1βR蛋白表达水平显著性高于正常对照组，且两组间比较具有显著性差。异（P<0.01）。结论E2对原发性肝癌的发生发展具有促进作用，且改作用机制可能是通过上调IL-1/IL-1βR通路，促进VEGF的表达，引起肿瘤血管的形成而完成的。[关键词]雌激素；白细胞介素-1；白细胞介素-

3、1受体；原发性肝癌[中图分类号]TQ460.7[文献标识码]AMechanismofprimarylivercancerpromotinghormonepathwaythroughIL-1/IL-1R[Abstract]ObjectiveToinvestigatewhetherestrogenE2(Estradiol,E2)forthedevelopmentofprimarylivercancerarepromoted,aswellasthemechanismofactionisthroughinterleukin-1(Interleukin-1,IL-

4、1)/IL1receptor(Interleukin-1receptor,IL-1R)pathway.MethodsSelectedmalepatientswithprimarylivercancerastheobservationgroupofourhospitalfromJanuary2013toJune2014.Selectedthesameperiodofnon-primarylivercancerpatientsasnormalcontrolgroup,thepatientsweredetectedbyELISAserumE2,IL-1βand

5、VEGFconcentrationsweredetectedbyWesternblotinlivertumortissueandnormallivertissueandIL-1βRE2Rproteinlevels.ResultsSerumobservationgroupE2,IL-1β,andvascularendothelialgrowthfactor(VascularEndothelialGrowthFactor,VEGF)weresignificantlyhigherthanthenormalcontrolgroup,andbetweenthetw

6、ogroupswassignificantdifference(P<0.01);ObserverGroupE2RtumortissueandIL-1βRproteinlevelsweresignificantlyhigherthanthenormalcontrolgroup,andbetweenthetwogroupswassignificantdifference(P<0.01).ConclusionThedevelopmentofE2topromotetheroleofprimarylivercancer,andthemechanismofactio

7、nmaylocatedintheTomb,DongShenJiabang,deferthenextdayfocusedontheassassination.Linping,Zhejiang,1ofwhichliquorwinemasters(WuzhensaidinformationisCarpenter),whogotAfewbayonets,duetomissedfatal,whennightcamebechangedbyupregulatingIL-1/IL-1βRpathwaypromotestheexpressionofVEGF,causing

8、theformationoftumorbloodvesselsandcomple