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1、正常妊娠中晚期血脂系列指标变化的探讨张铭1,王慧艳2*,张一鸣1,马纹2(1南京医科大学附属常州市妇幼保健院检验科,江苏常州213003;2南京医科大学附属常州市妇幼保健院产科,江苏常州213003)摘要目的观察并分析正常妊娠中晚期血脂代谢的特点。方法选取孕24~28周平均年龄(28.37±3.40)年龄在岁、孕29~32周平均年龄(28.17±3.09)岁、孕33~36周平均年龄(27.63±3.16)岁、孕37~41周平均年龄(27.47±2.96)岁4组共345例正常妊娠孕妇作为研究对象具体具体数量?一般状况分布?,抽取空腹静脉血,测定总胆固醇(TC)、甘油三脂(T
2、G)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、LP(a)、游离脂肪酸(NEFA),并计算APOA1/APOB比值。结果妊娠中晚期血清TG与NEFA水平变化趋势一致,随孕周增加而上升,在分娩前达到最高峰血清(P<0.05);血清HDL-C、APOA1水平和APOA1/APOB变化趋势一致,随孕周增加而下降(P<0.05);LDL-C和TC水平随孕周增加呈先上升后下降的趋势(P<0.001),在孕晚期37周前达高峰;APOB、Lp(a)在孕中、晚期均变化不明显,4组的水平无明显差异(P>0.05)
3、结论正常妊娠中晚期血脂代谢发生明显改变,各指标变化趋势不完全相同;应重视妊娠中晚期孕妇血脂水平检测。关键词妊娠;血脂;代谢紊乱中图分类号R446文献标识码AThestudyofInvestigatingserumlipidchangesofnormalpregnancyinthesecondandthirdtrimestersofnormalpregnancyZHANGMing1,WANGHuiyan2*,ZHANGYiming1,MAWen2(1.DepartmentofClinicalLaboratory,ChangzhouMaternalandChildHealth
4、CareHospitalAffiliatedtoNanjingMedicalUniversity,Changzhou213003,Jiangsu,China2.Departmentofobstetrics,ChangzhouMaternalandChildHealthCareHospitalAffiliatedtoNanjingMedicalUniversity,Changzhou213003,Jiangsu,China)[Abstract]0bjectiveToinvestigatingandanalyzethecharacteristicsofserumlipidme
5、tabolisminthesecondandthirdtrimestersofnormalpregnancy.Methods345Womenofnormalpregnancyinthesecondandthirdtrimesterswererecruitedinthefollowing4groups.:.ThelevelsofsSerumlipidlevelsweremeasured,includingtotalcholesterol(TC),triglyceride(TG),high-densitylipoproteincholesterol(HDL-C),low-de
6、nsitylipoproteincholesterol(LDL-C),apolipoproteinA1(ApoA1),apolipoproteinB(ApoB),lipoprotein(a),nonesterifiedfattyacids(NEFA).TheratioofApoA1/ApoBwascalculated.ResultsThelevelsofserumTGandNEFAinthesecondandthirdtrimestersrosewiththeincreaseofgestationalweeksageandreacheditstheirpeakbefore
7、delivery(P<0.05);ThelevelsofserumHDL-C、APOA1andtheratioofAPOA1/APOBdeclinedwiththeincreaseofgestationalageweeks(P<0.05);LDL-CandTClevelsbegantodeclineaftertheyreachedtheirpeaklevelin37pregnantweeks;showedatrendoffallingafterrisingfirst(P<0.001)withtheincreaseofgesta