论文资料：盐酸雷尼替丁中空微球的制备及其特性

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1、精品文档免费阅读免费分享如需请下载！盐酸雷尼替丁中空微球的制备及其特性魏郁梦，赵领，于明安*（重庆医科大学药学院药剂教研室，重庆400016）摘要：目的以盐酸雷尼替丁（RH）为模型药物，研究中空微球的制备，并对制备过程中的影响因素进行考察。方法以乙基纤维素(EC)为载体材料，乙醇/乙醚为混合溶剂，采用溶剂扩散－挥发法制备盐酸雷尼替丁中空微球。以产率、平均粒径、载药量和微球形态为指标，考察了处方工艺对微球性能的影响。并考察了EC粘度，RH/EC比例以及粒径对微球释药速率的影响。结果中空微球产率为84.51％，粒径分

2、布均匀，平均粒径632μm，载药量13.71％。电镜扫描显示：微球外观圆整光滑，内部为中空结构。体外释药研究表明随着EC粘度的增加释药速率降低；随着RH/EC比例和搅拌速度的增加释药速率增加。最终所得到的中空微球缓释可达24h，体外漂浮实验表明在人工胃液中可持续漂浮48h以上。结论该处方工艺简便可行，制得的盐酸雷尼替丁中空微球在人工胃液中缓释性和漂浮性良好。中空微球有望成为吸收窗药物的又一新型给药系统。关键词：盐酸雷尼替丁；中空微球；溶剂扩散－挥发法；漂浮中图分类号：文献标识码：文章编号：Preparationa

3、ndCharacteristicsofRanitidineHydrochlorideHollowMicrospheresWEIYu-meng,ZHAOLing,YUMing-an(SchoolofPharmaceutics,ChongqingMedicalUniversity,Chongqing400016,China)SUMMARY:OBJECTIVEThestudyinvolvespreparationandevaluationofhollowmicrosphereswithranitidinehydroch

4、loride(RH)asamodeldrug.METHODSHollowmicrospherescontainingranitidinehydrochloridewerepreparedbyasolventdiffusionandevaporationmethodusingethylcellulose(EC)ascarriermaterialandethanol/etherasorganicsolvents.Theyield,meandiameter(MD),drugloadingefficiency（LE）an

5、dshapeofmicrosphereswereusedtoevaluatetheinfluenceofdifferentformulationsandpreparationfactors.EffectsoftheECviscidity,RH/ECratioanddiameterduringpreparationonthedrugreleasefrommicrosphereswerealsoobserved.RESULTSTheyieldofthehollowmicrosphereswas84.51%,theme

6、andiameterwas632μmandthedrugloadingefficiencywas13.71％.Thescanningelectronmicroscopeconfirmedtheirhollowstructures，withsmoothsurfaces.TheinvitroreleasestudyshowedthatthedrugreleaseratedecreasedwithincreasingtheECviscidity，whileincreasedwithincreasingtheRH/ECr

7、atioandthediameter.Thepreparedmicrospheresexhibitedprolongeddrugrelease(approximately24h)andremainedbuoyantmorethan48hinartificialgastricjuice.CONCLUSIONThepreparedRHhollowmicrospheresshowedprolongeddrugreleaseandexcellentfloatability.Thoseresultssuggestthatt

8、hehollowmicrosphereshavegoodpotentialforsomeabsorptionwindowdrugs.KEYWORDS:ranitidinehydrochloride;hollowmicrospheres;solventdiffusionandevaporationmethod；float作者简介:魏郁梦，女，在读硕士通讯作者:于明安，男，副