通痹颗粒对冠心病心绞痛合并肥胖(痰瘀阻络证)患者et及no水平影响临床的研究

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1、中文摘要目的：观察通痹颗粒对冠心病心绞痛合并肥胖患者的临床疗效，血浆中内皮素（ET）及血清一氧化氮（NO）水平的影响，探讨通痹颗粒治疗冠心病心绞痛合并肥胖患者的作用机制。方法：将门诊及住院的60例冠心病心绞痛合并肥胖患者，随机分为两组，分别给予常规西药治疗和常规西药基础上加服通痹颗粒治疗。疗程为4周，治疗前后做心电图，检测血浆中内皮素与血清一氧化氮水平。内皮素检测用放射免疫法，一氧化氮检测采用还原酶法。结果：两组患者治疗后中医证候疗效优于治疗前，组间比较显示治疗组优于对照组，具有显著性差异（P＜0.05）。两组治疗后心绞痛疗效及心电图疗效较

2、治疗前均有所改善，组间比较两组治疗后无显著性差异(P＞0.05)。两组在硝酸甘油停减率比较上有显著性差异（P＜0.05），治疗组疗效优于对照组。两组患者治疗后血浆内皮素及血清一氧化氮水平明显改善，与治疗前比较有显著性差异（P＜0.01）；组间比较显示治疗组优于对照组，具有显著性差异(P＜0.05)。结论：通痹颗粒对冠心病心绞痛合并肥胖患者的临床疗效确切，能显著降低患者血浆内皮素含量，升高血清一氧化氮含量，说明本方具有改善血管内皮及保护血管内皮的功能，该方还能调脂、增加冠脉血流量，实现对缺血心肌的保护作用。关键词：冠心病心绞痛；肥胖；通痹颗粒

3、；内皮素；一氧化氮ClinicalresearchoneffectsofplasmaETandNOlevelsofTongbigranulesonCHDanginapectorispatientswithobesityAbstractObjective:observedtheclinicalcurativeeffectandexaminedtheplasmaendothelin(ET)andserumnitricoxide(NO)levelsoftheTraditionalChineseherbTongbigranulesonCHDang

4、inapectorispatientswithobesity,toexplorethemechanismofTongbiGranuleonCHDanginapectorispatientswithobesity.Methods:60CHDanginapectorispatientswithobesity,whocamefromtheoutpatientandinpatientdepartment,weredividedrandomlyintotwogroups:onegroupwastreatedwithconventionalwester

5、nmedicineandanotherwiththeTraditionalChineseherbTongbigranulesaswellasconventionalwesternmedicine.Thetreatmenttimewas4weeks.MadeECGexaminationtothepatientsbeforeandafterthetreatmentanddetectedtheirplasmaETandserumNOlevel.ETbyradioimmunoassayandNOweredetectedbyreductasemeth

6、od.Results:TheefficacyofTCMsyndromeofthetwogroupsaftertreatmentswerebetterthanthosebeforetreatments.groupscomparisonshowedthatthetreatmentgroupthanthecontrolgroup,withsignificantdifference(P<0.05).ThetwogroupsaftertreatmentcomparedwithbeforetreatmentanginapectorisandECGwer

7、eimproved.groupscomparison,thetwogroupsaftertreatmentshowednosignificantdifference(P>0.05).therateofstoporlessofthetwogroupsinnitroglycerin,therewassignificantdifference(P<0.05),treatmentgroupwasmoreeffectivethanthecontrolgroup.Comparedwithbeforetreatment,theplasmaETandse

8、rumnitricoxide(NO)levelsweresignificantlyimprovedafterthetreatment,bothofthemshowedthatth