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1、神经营养因子与退行性神经系统疾病来源：解剖科学进展作者：王昭金万选才2004-9-30摘 要：近年来随着对神经营养因子作用研究的不断深入，人们提出了神经营养因子是否对退行性或创伤中枢神经系统疾病有治疗作用的问题，本文将综述神经营养因子在生物学方面的最新发现，特别是神经营养因子的作用、及有关对中枢神经退行性疾病可能有治疗作用的内容参考文献： ［1］ParttersonPHandNawaH.Neuronaldifferentiationfactor/cytokinesandsynapticplasticity.Neuron,1993,10(6):3507 ［2］IpNY.C
2、NTFandLIFactonneuronalcellsviasharedsignalingpathwaysthatinvolvetheIL-6gignaltransducingreceptorcomponentgp130.Cell,1992,69(5):1121 ［3］IPNYandYancouplosCD.Neurotraphicfactorsandtheirreceptors.Annneurol,1994,35(1):s9 ［4］ClaterbuckREandPriceDL.Furthercharacterizationoftheeffectsofbrain-der
3、ivedneurotrophicfactorandciliaryneurotrophicfactoronaxotomizedneonatalandadultmammalianmotorneurons.JCompneurol,1994,342(1):45 ［5］KorschingS.Theneurotrophicfactorconcept:areexamination.JNeurosci,1993,13(8):2739 ［6］SendmerM,KreutzberyGMandThoenenH.Ciliarynerurotrophicfactorpreventsthedege
4、nerationofmotorneuronsafteraxotomy.Nature,1990,345(2):440 ［7］KnuselBandWinslowJW.Promotionofcentralcholinergicanddopaminergicneurondifferentiationbybrain-derivedneurotrophicfactorbutnotneurotrophin-3.ProcNatlSciUSA,1991,88(3):961 ［8］ZhouJ,Pliego-RivevoB,BradfordH,etal.TheBDNFcontentofpos
5、tnatalandadultratbrain,theeffectsof6-hydroxydopaminelesionsinadultbrain.DevelopBrainres,1996,97(2):273 ［9］HymanCandHoforM.BDNFisaneurotrophicfactorfordopaminergicneuronsofthesubstantianigra.Nature,1991,350(2):230 ［10］HaqueNSK,HlauimML,FawcettJW,etal.TheneurotrophinNT-4/5,butnotNT-3,enhan
6、cetheefficacyofnigralgraftsinaratmodelofParkinson’sdisease.Brainres,1996,712(1),45 ［11］SiuciakJK,BoylanC,FristehM,etal.BDNFincreasemonoaminergicactivityinratbrainfollowingintracerebroventricularorintraparenchymaladministration.Brainres,1996,712(1):11 ［12］Levi-MontalciniR.Thenervegrowthfa
7、ctor35yearslater.Science,1987,237(7):1154 ［13］AldersonRFandAltermanAl.Brain-derivedneurotrophicfactorincreasessurvivalanddifferentiatedfunctionsofratseptalcholinergicneuronsinculture.Neuron,1990,5(1):297 ［14］DistefanoPS.TheneurotropinBDNF,NT-3,andNGFdisplayd
