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1、工业生物催化技术（Industrialbiocatalysistechnology）May2003bowelprocess,volumefirst,first12,ChineseJournalofBioprocessEngineering,May2003IndustrialbiocatalysistechnologyLinLin,CaoZhuan,XingXinhui,LiuZheng(Instituteofbiochemicalengineering,Departmentofchemicalengineering,TsinghuaUniversity,Beijin
2、g100084,China)Abstract:industrialbiocatalysistechnologyinengineeringapplicationofproteinenzymeasthecore,isconsideredtobefollowingthebiopharmaceuticalandbiotechnologyforplantaftertheturnoutsThethirdwave.Itsdevelopmentandapplicationwillbringaboutaradicalchangeintheindustrialprocessofhuma
3、nbeings.TheriseofindustrialbiocatalysisandthefollowingtwoconcernsThereisacloserelationshipbetweenthetechnologicalfactors:(1)thedevelopmentofproteindirectedevolutiontechniques;(2)thedevelopmentofgenomicsandproteomics.DiscussiononindustrialstarchThepresentsituationanddevelopmenttrendofca
4、talytictechnology,andsomesuggestionsonhowtodevelopthebaseandapplicationofthiscityareputforward.GuanJian:industrialbiocatalysis;biologicaltransformation;directedevolution;genomics;ProteomicsCLCnumber:814.2,documentidentificationcode:A,articlenumber:1672,3678(2003),01,one,0012,one,05Indu
5、strialbiocatalysisLINZhang-lin,CAOZhu-an,XINGXin-hui,LIJZheng(DepartmentofChemicalEngineering,T,onyhuaUniversity,Beijing100084,China)Abstract:Biocatalysis,theuseofenzymesinindustrialprocesses,is,ideredthethudwaveofbiotechnol-RevolOgy(afterbiomedicineandtransgenicplants).Ithasthepotenti
6、altoutionizethetraditionalchemistry1Relatedindustries.Therapidadvanceinbiocatalysissincehate1990'6hasbeendrivenfieldtwocriticalfactors:(1)newtoolsforenzymeengineeringsuchasdirectedevolution,whichmakeitpossibletotailorenzymesforIndustrialuses;and(2)thegerromicsandproteomicsresearch,whic
7、hhasprovideahugerepertoireofen-Zymesaswellasnewbiosyntheticroutes.CurrentstatusanddevelopmenttrendsinbiocatalysisarereviewedinThisreport,alongwithseveralstrategicrecommendationsforthisimportantareaofR&DinChina.Keywords:biocatalysis;enzymeengineering;directedevolution;genomics;Proteom
