乳腺癌节拍化疗课件

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1、节拍化疗在乳腺癌中的应用节拍化疗vs传统化疗节拍化疗：小剂量化疗药、频繁、规律给药传统化疗：最大耐受剂量、每3周间隔给药传统化疗节拍化疗MetronomicChemotherapy--aMulti-targetedChemotherapyNumberofpublishedpapersovertheyearsNumberofpublishedpapersaccordingtocountry/region节拍化疗在乳腺癌中的应用晚期乳腺癌：姑息化疗，尤其是老人、多线治疗患者早期乳腺癌：辅助化疗/新辅助化疗Metro

2、nomicDrugCyclophosphamideMethotrexateFluorouracil:FT207/UFT/CapecitabineEtoposideVinorelbineTemozolomideTaxanespegylatedliposomaldoxorubicinIrinotecanCisplatin口服便宜耐受好MetronomicSchedulePuremetronomicchemotherapyMetronomicchemotherapy+HormonaltherapyMetronomic

3、chemotherapy+TargetedtherapyMetronomicchemotherapy+TmmunologicagentsMetronomicchemotherapy+DrugrepositioningAuthorandyearNpatientsTreatmentPhasePrevioustreatmentandsettingORR(%)CB(%)OS(months)Colleoni200263Cyclophosphamide+MethotrexateIIPretreatedMBC1931.7%/

4、Orlando2006153Cyclophosphamide+MethotrexateRetrospectivePretreatedMBC/15.7%withCB>12m/Orlando200622Cyclophosphamide+Methotrexate/PretreatedMBC1846/Miscoria201262Cyclophosphamide+MethotrexateIIPretreatedMBC//7.1Perroud201315Cyclophosphamide+MethotrexateII/6.7

5、46.7/Smith201033OralfluorouracilIINotPretreatedMBC55Tagushi201033CapecitabineIINotPretreatedMBC184424.8Fedele201260CapecitabineIIPretreatedMBC246217Dellapasqua200846Cyclophosphamide+Capecitabine/PretreatedMBC4868/Wang201268Capecitabine+CyclophosphamideIIPret

6、reatedMBC30.35316.9Yoshimoto201251Capecitabine+CyclophosphamideIIPretreatedMBC4457.8/Montagna201224Capecitabine+CyclophosphamideIINotPretreatedMBC6275/Addeo201034VinorelbineIINotPretreatedMBC3815.9Saridaki201235Vinorelbine+CapecitabineIPretreatedMBC46//Cazza

7、niga201412+22Vinorelbine+CapecitabineI–IIPretreatedMBC/58/Otsuka201340Irinotecan+Tegafur//47/26Dellapasqua201129Liposomaldoxorubicin+cyclophosphamide/NotpretreatedLocallyadvanced69//OngoingPuremetronomicstudiesSchedulephaseSettingRef.Capecitabine1000m/m2d1–1

8、4+VNB60mg/m2d1,8q21dvs.VNB50mg/dd1,3,5/wkIIRandomizedM+,<1lineNCT01941771StandardADJCT+Capecitabine650mg/m2bidIIIADJ,TNNCT01112826SYSUCC-001PTX100mg/m2/wkx8DOX24mg/m2/wk+CTX100mg/d9wksIILocallya