利多卡因复合丙泊酚在无痛胃镜中的应用

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1、利多卡因复合丙泊酚在无痛胃镜中的应用【摘要】目的探讨小剂量低浓度利多卡因复合丙泊酚应用于无痛胃镜检查与治疗的临床效果。方法将800例行胃镜检查与治疗的患者随机分为两组各400例，研究组应用小剂量低浓度利多卡因复合丙泊酚麻醉，对照组单用丙泊酚麻醉；两组在麻醉前采用心电监测仪监测血压、血氧饱和度、心率、呼吸频率及心电图，取左侧卧位鼻导管吸氧，开放右前臂静脉通道。记录术中两组应用丙泊酚剂量、用药时患者局部刺激反应情况、体动情况、呼吸暂停及心电监测仪监测结果进行对比分析。结果研究组麻醉时局部刺激反应发生率、术

2、中体动发生率（咽反射、四肢活动）、丙泊酚应用剂量均显著低于对照组（P＜0.05或0.01）；未发生呼吸暂停现象，患者及胃镜医师满意度均为100%，优于对照组，但无差异性（P＞0.05）。两组心电监测仪监测结果均在正常范围内，但研究组血压、血氧饱和度、心率、呼吸频率较小，SPO2高于对照组。结论小剂量低浓度利多卡因联合丙泊酚较单用丙泊酚应用于无痛胃镜检查及治疗效果更显著，且生命体征平稳，安全性更高，适用于无痛胃镜的检查与治疗。【关键词】无痛胃镜技术；利多卡因；丙泊酚；麻醉；不良反应【Abstract】O

3、bjectiveToexploretheclinicalefficacyofsmalldoselightconcentrationlidocainecombinedwithpropofolinanalgesiagastroscopyandtreatment.Methods8007patientswhoreceivedgastroscopyandtreatmentwererandomlydividedintoresearchgroup(n=400)anesthetizedwithsmalldose

4、light-concentrationlidocainecombinedwithpropofolandcontrolgroup(n=400)withpropofolonly;beforeanesthesia,BP,bloodoxygensaturation(BOS),HR,respiratoryrate(RR)andECGweremonitoredusingelectrocardioscanner,theyinhaledoxygenvianasalcathetertakingleftlateralpo

5、sitionandopenedrightforearmveinchannel.Suchparametersaspropofoldose,patients’localstimulusreaponseonmedication,bodymovements,apneaandmonitoringresultsofelectrocardioscannerwererecordedandcontrstiveanalyzedforbothgroupsduringoperation.ResultsLocalstimulu

6、sreaponseandintraoperativebodymovements(pharynxandlimbs’activities)incidenceandappliedpropofoldosageweresignificantlylowerintheresearchthaninthecontrolgroup(P<0.05or0.01);intheresearchgroup,therewasnoapnea,degreesofsatisfactionforbothpatientsandgastr

7、oscopephysicianswere100%,whichhaveanadvantageovercontrolgroup,butdifferencewasnosignificant(P>0.05).Monitoringresultsofbothgroupswerewithinnormallimits,butBP,BOS,HRandRRwerelowerandSPO2higherintheresearchthaninthecontrolgroup.ConclusionEffectsofsmall

8、doselightconcentrationlidocainecombined7withpropofolinanalgesiagastroscopyandtreatmentaremoresignificant,patients’vitalsignsstable,safetyhigherandpracticalinanalgesiagastroscopyandtreatment.【Keywords】Analgesiagastroscopy;lidoca