低频脉冲电针对慢性根性痛大鼠背根神经节p物质的影响

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1、低频脉冲电针对慢性根性痛大鼠背根神经节P物质的影响作者：屠文展，蒋松鹤，楼新法，张瑞峰，刘芬，庞玲霞，李莎莎【摘要】目的:探讨局部及肢体远端不同穴位低频脉冲电针对慢性根性痛大鼠背根神经节P物质（sP）的影响。方法:复制慢性根性痛大鼠模型。将25只雄性Wistar大鼠随机分为正常对照组、模型组、局部电针组（取双侧L4“夹脊”穴）、远端电针组（取双侧“阳陵泉”穴）及远近结合电针组（取双侧L4“夹脊”穴＋双侧“阳陵泉”穴）。通过免疫组化法，观察比较患侧背根神经节sP表达的变化。结果:与模型组相比，正常组、电针组患侧背根神经节s

2、P的表达均减少（P<0.05）。各电针组之间，远近结合电针组患侧背根神经节sP的表达较局部电针组、远端电针组减弱（P<0.05）。结论:低频脉冲电针的镇痛作用可能部分是通过抑制sP的合成实现的。与局部电针组和远端电针组相比，远近结合电针组抑制sP的合成作用较强。【关键词】低频脉冲；电针；P物质；慢性根性痛；脊神经节Abstract:Objective:ToinvestigatetheeffectofsubstancePindorsalrootgangliontreatedwithlowfrequency9tr

3、ansductionpulseelectro-acupunctureondifferentacupointsoflocalanddistantlimbsofthechronicradicularpainrats.Methods:Themodelofratwithchronicradicularpainwasadoptedand25malenessWistarratsweredividedintothreegroupsrandomly，includingnormalcontrolgroup，modelgroup，local

4、acupointsneedlinggroup（chooseGB34Yanglingquanateachside），distantacupointsneedlinggroup（chooseEX-B2JiajiateachsideofL4）；distantandlocalcoordinationofacupointsneedlinggroup（chooseGB34tYanglingquanateachsideandEX-B2JiajiateachsideofL4）.Thechangesoftheexpressionofsub

5、stancePinthedorsalrootganglionwereobservedbytheimmunochemistry.Results:Comparedwiththemodelgroup，theexpressionofsubstancePinthedorsalrootganglioninthenormalcontrolgroupandelectroacupuncturegroupswerelowersignificantly(P<0.05)．Amongtheelectroacupuncturegroups，t

6、heexpressionofsubstancePindistantandlocalcoordinationofacupointsneedlinggroupwerelowersignificantly(P<0.05)comparedwithlocalacupointsneedlinggroupanddistantacupointsneedlinggroup.Conclusion:Theanalgesiaeffectoflowfrequencytransductionpulseelectro-acupunctureis

7、realizedbysuppressingthesynthesisofsubstancePtosomeextent.Comparedwithlocalacupointsneedlinggroupanddistant9acupointsneedlinggroup，distantandlocalcoordinationofacupointsneedlinggroupeffectsbetterininhibitingthesynthesisofsubstanceP.Keywords:lowfrequencytransducti

8、onpulseelectroacupuncture；substanceP；chronicradicularpain；immunochemistry；ganglia低频脉冲电针是将物理医学与中医针灸学相结合治疗慢性腰腿痛的有效而副作用极少的一种手段。已有大量动物实验证实低频脉冲电针是通过调节神经递质的表达和释放而起到镇