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1、安心颗粒对血脂紊乱家兔血脂及主动脉超微结构的影响作者：方显明，袁颖，吴韫宏，尹雪曼【关键词】,安心颗粒［摘要］目的：研究安心颗粒对家兔实验性血脂紊乱的防治作用。方法：采用食饵性血脂紊乱新西兰家兔为模型，以脂必妥片为对照药，观察安心颗粒对血脂、主动脉超微结构的影响。将32只新西兰家兔随机分为正常对照组、模型组、脂必妥片组、安心颗粒组等4组，分别给予普通饲料、高脂饲料、高脂饲料加脂必妥片、高脂饲料加安心颗粒。10周后，测定各组动物血清总胆固醇（totalcholesterol,TC）、甘油三酯（triglycerides,TG）、低密度脂蛋白
2、胆固醇（lowdensitylipoproteincholesterol,LDLC）、高密度脂蛋白胆固醇（highdensitylipoproteincholesterol,HDLC）、载脂蛋白A1（apolipoproteinA1,ApoA1）、载脂蛋白B（apolipoproteinB,ApoB）水平，同时用电镜观察主动脉超微结构。结果：安心颗粒可以显著降低血脂紊乱新西兰兔血清TC、TG、LDLC、ApoB水平；电镜下主动脉超微结构观察显示：安心颗粒组主动脉硬化病变较模型组和脂必妥片组轻，血管内皮细胞质内偶见小脂滴空泡，各种细胞器存在
3、，内弹力膜存在，中层平滑肌细胞质内无脂滴空泡。结论：安心颗粒能调节兔的血脂代谢，对动脉粥样硬化病变有明显的抑制作用。11 ［关键词］安心颗粒;血脂紊乱;模型,动物;主动脉;超微结构 EffectsofAnxinGranulesonbloodlipidandultrastructureofaortainrabbitswithdyslipidemia ABSTRACTObjective:TostudytheeffectsofAnxinGranulesondyslipidemiainrabbitscausedbyhighfatplush
4、ighcholesteroldiet.Methods:ThirtytwohealthyNewZealandmalewhiterabbitswererandomlydividedinto4groups:normalcontrolgroup,untreatedgroup,ZhibituoTablettreatedgroupandAnxinGranuletreatedgroup.Rabbitsinthenormalcontrolgroupwerefedwithregularchow,whilerabbitsintheotherthreegrou
5、pswerefedwithhighfatplushighcholesteroldiet.ZhibituoTabletsandAnxinGranuleswereadministeredtotherabbitsinZhibituoTablettreatedgroupandAnxinGranuletreatedgroupatadailyoraldoserespectively.Attheendofthe10thweek,thelevelsofserumtotalcholesterol(TC),triglycerides(TG),highdens
6、itylipoproteincholesterol(HDLC),lowdensitylipoproteincholesterol(LDLC),apolipoproteinA1(ApoA1)andapolipoproteinB(ApoB)weretestedineachgroup,11andtheultrastructuresoftheaortawerealsoobservedbyanelectronmicroscope.Results:AnxinGranulescouldreducethelevelsofTC,TG,LDLCandApoB
7、.Theresultsobservedbyelectronmicroscopeshowedthat,ascomparedwiththeuntreatedgroupandtheZhibituoTablettreatedgroup,theatherosclerosisofaortaintheAnxinGranuletreatedgroupwaslighter.Anditwasfoundthattherewerefewlipiddropletvacuolesincytoplasmoftheendothelialcells,andvariousc
8、ellorgansandelasticmembranewereexisted,butnolipiddropletvacuolesincytoplasmofthemedialsmoothmusc
