压力负荷性大鼠肥厚心肌中angⅱ受体的表达

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1、压力负荷性大鼠肥厚心肌中AngⅡ受体的表达作者：王晓虹，刘进军，苏兴利，高广道【关键词】卡托普利；心肌肥厚；AT1受体；AT2受体　　摘要：目的观察压力负荷性肥厚心肌中AngⅡ受体两种亚型AT1与AT2的表达变化及captopril干预对其表达的影响。方法选用腹主动脉缩窄方法制造压力负荷大鼠模型，观察压力负荷性大鼠心肌肥厚程度及心肌中AT1与AT2表达的变化。结果AC术后大鼠左室心肌肥大指数进行性加重，AC术后captopril干预可抑制心肌肥大发展；心肌中AC组心肌AT1受体的表达随AC的持续时间而不断上升，而AT2的表达仅在AC术后一过性增高，后随着左室负荷的持续而回降到对照

2、水平，AT1/AT2值在AC术后1周时轻度升高，而后进行性降低；血管紧张素转换酶抑制剂(ACEI)AC术后干预在抑制心肌肥大发展的同时，显著抑制了心肌中的AT1表达，使AT1/AT2值显著回降。结论持续压力负荷增高引起心肌中AT1表达进行性增高，而对AT2的表达仅表现为早期一过性影响。ACEI干预可显著降低持续压力负荷性心肌中的AT1表达，从而有效阻止了AngⅡ通过AT1介导启动的心肌肥厚效应。15　　关键词：卡托普利；心肌肥厚；AT1受体；AT2受体　　ExpressionofAngⅡreceptorsinexcessloadpressured　hypertrophiedcar

3、diacmusclesofrats　　ABSTRACT:ObjetiveTostudytheeffectsofcaptoprionAT1andAT2receptorsofloadpressuredhypertrophiedcardiacmusclesofadultrats.MethodsUsingthemethodsofnarrowingandcontractionoftheaortaofadulthealthyratstoestablishthemodelofanimalswithhypertrophiedcardiacandtoobservethechangesofrecep

4、torsAT1andAT2ofhypertrophiedcardiacmusclesofACratsbycomprehensiveapplicationsofcardiactube,immunitytissuechemistryandthetechniqueofimagedisjunction.ResultsLeftventricularandcardiacmusclesofratswereincreasedremarkablyasthepressureloadingtimelasted.Afterusingcaptopri,leftventricularhypertrophie

5、donewasdecreasedmoresignificantlythanthatincontrolgroup.TheexpressionofreceptorAT1wasincreasedremarkablyasthepressureloadingtimelasted.TheexpressionofreceptorAT2wasincreasedtransiently,afterthatreachedaboutashighascontrolgroup.AT1/AT2wasincreasedoneweekafteroperation,andthenwasprogressivelyde

6、creased.AfterAC,captopri15preventedhypertrophiedcardiacmusclesandreceptorAT1incardiacmuscles.AT1/AT2wasremarkablydecreased.ConclusionLoadpressuredcardiachypertrophymayincreasetheexpressionofAT1.TheexpressionofreceptorAT2wasincreasedtransiently.Themainworkingmechanismofcaptoprispreventingandtr

7、eatingtheloadpressuredcardiachypertrophyinadultratsmaybeloweringtheexpressionofAT1andmayeffectivelyblockthecardiachypertrophyregulationprecessofAngllviaAT1preventingloadpressuredcardiachypertrophyinadultrats.　　KEYWORDS:captopril;cardiachypert