kai-1在肾细胞癌中的表达及意义

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1、KAI-1在肾细胞癌中的表达及意义作者：张录芳，潘东亮　彭学叶，尹哲［摘要］目的研究KAI-1在不同分期、分级、预后和年龄组肾细胞癌中的表达，分析其表达的意义。方法随访1991～2000年入院治疗并留取病理标本的肾癌病例预后。根据临床分期、细胞分级、年龄、T1-3aN0M0病例是否术后转移分别将肾癌病例分组，应用免疫组织化学方法检测肾癌标本KAI-1表达，卡方检验分析KAI-1表达的差异。结果30～70岁每十年龄段KAI-1阴性表达率为34.4%～47.8%，比较低表达率χ2值为0.54～1.19，P均>0.05，过表达率χ2值为

2、0.84～1.84，P均>0.05。肾癌TNMⅠ～Ⅳ期KAI-1阴性表达率为34.2%、25.2%、54.4%和80.0％，Ⅰ、Ⅲ、Ⅳ期间过表达比较P<0.05。Fuhrman分级Ⅰ～Ⅲ级KAI-1阴性表达率为33.0%、47.8%、81.4%，Ⅱ和Ⅲ、Ⅰ和Ⅲ级比较χ2值分别为9.11、27.24，P均<0.01。T1-3aN0M0术后转移组24例和未转移组194例KAI-1阴性表达率为79.2％、9.8％；两组低表达率比较χ2值＝64.49，P<0.01；过表达χ2值＝0.02，P>0.05。结论转移抑制

3、基因KAI-1在肾癌中的表达与年龄因素无关。KAI-1低表达或表达缺失率在Ⅲ期、Ⅳ期和FuhrmanⅢ级肾癌中最高。KAI-1基因缺失可能参与了T1-3aN0M0肾癌术后转移的发生，检测KAI-1表达具有临床预后指导价值。10［关键词］肾细胞；癌；KAI-1；转移抑制基因ExpressionofmetastasessuppressorgeneKAI-1onrenalcellcarcinomaanditssignificance［Abstract］ObjectiveTostudytheexpressionofmetastasessuppr

4、essorgeneKAI-1onrenalcellcarcinoma（RCC)andanalyzeitssignificance.MethodsThepatientswithRCCundergoingsurgicaloperationsfrom1991to2000werefollowedupandtheirprognoseswerewrittendown.Thenthesepatientsweredividedintodifferentgroupsaccordingtotheirclinicalstages，tumourcellgrad

5、ation，ageofpatientandwhetherpostoperativemetastasisofT1-3aN0M0stagepatientsoccurredornot.TheexpressionofKAI-1onRCClesionsweretestifiedwithimmunohistochemistryandtheoutcomesofexpressionwereanalyzedbyχ2testing.ResultsThedifferencesofKAI-1expressioneverydecadesamongagesof30

6、~70werenotstatisticallysignificant.Nevertheless，thenegativeexpressionratesofKAI-1fromTNMⅠtoⅣstagewere34.2%，25.2%，54.4%and80.0％individually，andthestatisticallysignificantdifferencesofKAI-1overexpressionbetweenⅠandⅢandⅣstage（P<0.05).Thenegativeexpressionbetween10Fuhrman

7、G1andG3，G2andG3werecomparedseparatelyandtheχ2scoreswere9.11，27.24（P<0.01).Twentyfourcaseswithpostoperativemetastasisand194caseswithoutpostoperativemetastasisinpatientsofT1-3aN0M0stagewerefoundoutbyfollow-up.ThelowexpressionrateofKAI-1inmetastasisgroupwashigherthanthat

8、ofnometastasisgroup（P<0.01).ConclusionThereisstatisticallysignificantcorrelationbetweentheexpression