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1、2型糖尿病周围神经病变中医证型与危险因素相关性分析作者：张广德,邹本良,刘蕊,黄佳娜【摘要】目的探讨2型糖尿病周围神经病变(T2DPN)中医证型与危险因素间的关系。方法回顾性分析112例T2DPN病例,收集其年龄、病程、体重指数(BMI)、糖化血红蛋白(HbA1c)、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血肌酐(Cr)、空腹C肽(CP)、餐后2hC肽(P2hCP)等指标。遵循《糖尿病中医防治指南》对入组病例进行辨证分型,并对上述资料进行数据分析。结果气虚血
2、瘀证与痰瘀内阻证相似,与阴虚血瘀证、肝肾亏虚证比较病程差异有统计学意义(P<0.05);气虚血瘀证、肝肾亏虚证、痰瘀内阻证SBP与阴虚血瘀证比较,差异均有统计学意义(P<0.05);HbA1c、TC和LDL-C三者相似,痰瘀内阻证与其他3个证型间差异均有统计学意义(P<0.05);阴虚血瘀证Cr、CP较其他3种证型差异也有统计学意义(P<0.05);痰瘀内阻证、肝肾亏虚证的P2hCP值与其他2种证型比较差异存在统计学意义(P<0.05)。结论按照阴虚血瘀证→气虚血瘀证→肝肾亏虚证→痰瘀内阻证顺序,T2DPN病情有逐步加重的趋势
3、。【关键词】2型糖尿病周围神经病变;中医证型;危险因素;相关性分析9 Abstract：ObjectiveTodiscusstherelativitybetweenriskfactorsandTCMsyndrometypesoftype2diabetesmellitusperipherialneuropathy(T2DPN).MethodsOnehundredandtwelvecasesofT2DPNinpatientswereretrospectiveanalyzed.Therelatedclinicaldatasuchasage,courseofdi
4、sease,HbA1c,SBP,DBP,TC,TG,HDL-C,LDL-C,Cr,CP,P2hCPwerecollected.TCMsyndrometypeswereclassifiedaccordingtoGuidelineforTCMDiabetesPreventionandTreatment.TherelationshipbetweenriskfactorsofT2DPNandTCMsyndrometypeswassummarizedbystatisticalanalysis.ResultsSignificantdifferenceswerefoun
5、dbetweenqideficiencywithbloodstasissyndromeandyindeficiencywithbloodstasissyndrome,andliver-kidneydepletionsyndromeinaspectofdiseasecourse(P<0.05),thesimilarresultcanbegottenwithphlegmandbloodstasisobstructingsyndrome(P<0.05).Significantdifferenceswerefoundbetweenyindeficien
6、cywithbloodstasissyndromeandothertypesinaspectofSBP(P<0.05).SignificantdifferenceswerefoundbetweenphlegmandbloodstasisobstructingsyndromeandothertypesinaspectsofHbA1c,TCandLDL(P<0.05).Significantdifferenceswerefoundbetweenyindeficiencywithbloodstasissyndromeandothertypesinas
7、pects9ofCrandCP(P<0.05).Significantdifferenceswerefoundamongliver-kidneydepletionsyndrome,phlegmandbloodstasisobstructingsyndromeandtheothertwotypesinaspectofP2hCP(P<0.05).ConclusionTherearesometrendthattheconditionofT2DPNdevelopmoreseriousdowntheorderofyindeficiencywithbloo
8、dstasissyndrome→qideficiencywithb
