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1、兔VX2肝癌模型制备的改进及其磁共振影像学表现1121作者：全显跃；谢伟；张雪林；孙希杰；朱杏莉1111；严政；梁文(南方医科大学珠江医院影像中心，2广东广州510282；南方医科大学南方医院影像中心，广东广州510515)摘要：目的改进兔VX2肝癌模型的制作方法，使之更为简便、省时,同时探讨瘤灶的MRI表现及MRI在动态检测瘤灶中的作用。方法新西兰大白兔16只，随机分成4组(每组4只)，在螺旋CT引导下，采用瘤块组织接种于兔肝脏左、右叶，接种后14、18、22、26d分别行MRI平扫、增强扫描及病理分析。结
2、果16只实验兔发现瘤灶，成瘤率100%；瘤灶以种植后18～22dMRI显示最清楚和典型，直径1～2cm，平扫呈低或等信号,增强扫描瘤灶边缘明显强化，种植后超过22d的肿瘤中央坏死明显。结论螺旋CT引导下进行兔VX2肝癌模型的制作，使制作过程更为简便、省时；采用磁共振平扫及增强扫描对瘤灶进行动态检测、评价，可更为准确、及时地观察瘤灶的发生、发展等影像学改变。关键词：肝肿瘤；动物模型；螺旋CT；磁共振成像中图分类号：R737;R815文献标识码：A文章编号：1673-4254(2006)06-0747-03Mod
3、ificationofthemethodforpreparingrabbitliverVX2tumormodelanditsMRIfindings11211QUANXian-yue；XIEWei；ZHANGXue-lin；SUNXi-Jie；ZHUXing-li；11YANZheng；LIANGWen1ImagingCenter,ZhujiangHospital,SouthernMedicalUniversity,2Guangzhou510282,China;DiagnosticImagingCenter,N
4、anfangHospital,SouthernMedicalUniversity,Guangzhou510515,ChinaAbstract:ObjectiveToimprovethemethodforpreparingrabbitVX2livertumormodelandobservethemagneticresonanceimaging(MRI)featuresoftheimplantedtumors.MethodsSixteenadultNewZealandwhiterabbitswereassigne
5、drandomlyinto4equalgroups,andVX2tumortissueswereimplantedintotherightandleftliverlobeswithspiralCTguidance.Plainandcontrast-enhancedMRscannandpathologicalanalysiswereperformedindifferentstages(14,18,22and26days)aftertumorimplantation.ResultsTumorimplantatio
6、nwassuccessfulinalltherabbits,and18to22daysaftertumorimplantation,thediametersofthetumorrangedfrom1to2cm,whichallowedobservationandstudy.InplainMRscans,lowerorequivalenttumorsignalincomparisonwithhepaticparenchymawasobserved,andcontrast-enhancedscansproduce
7、dobviousenhancementofthetumoredges.At22daysaftertumorimplantation,obviousnecrosiswasobservedinthecenterofthetumor.ConclusionThismethodofpreparingrabbitVX2livertumormodelwithspiralCTguidanceissimpleandconvenient,andthetumorscanbeobservedeffectivelywithdynami
8、cplainandcontrast-enhancedMRscans.Keyword:liverneoplasms;animalmodel;spiralCT;magneticresonanceimaging收稿日期：2005-12-26基金项目：广东省自然科学基金(32830)SupportedbytheNaturalScienceFoundationofGuangdongProvince(32830
