卵巢环状小管性索瘤临床病理研究

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1、卵巢环状小管性索瘤临床病理研究【关键词】卵巢【摘要】目的阐明卵巢环状小管性索瘤的临床病理特点。方法通过对432例卵巢肿瘤进行病理复习并运用组织化学方法，结合临床资料，总结卵巢环状小管性索瘤的临床病理特点。结果432例卵巢肿瘤中仅3例确诊为卵巢环状小管性索瘤。为青、少年女性，主要表现为内分泌紊乱，且均不伴有PJS综合征，其中2例发生左锁骨上和/或腹膜后淋巴结转移;大体检查肿瘤呈灰黄色，单发，表面光滑，其中1例肿瘤可见囊性变;光镜下肿瘤以边界清楚的环状小管环绕玻

2、璃样基底膜样物质构成的小结为特征，形成单环状小管和复环状小管两种基本构型，肿瘤细胞胞浆淡染，胞核圆形，与原发性卵巢环状小管性索瘤相比，转移性肿瘤的瘤细胞具有不同程度异型性，分裂像≥4个/10HPF，单环状小管和复环状小管明显减少;PAS染色小管内嗜酸性物质及管周基底膜均阳性，网织染色见瘤细胞间有少量网状纤维。结论本病为罕见的低度恶性肿瘤，可发生远期转移，转移部位以淋巴结或周围脏器为主，因此术后应加强随访，既往史对诊断转移性肿瘤有帮助。关键词卵巢肿瘤环状小管性

3、索瘤临床病理Clinicopathologicalstudyofovariansex-cordtumorwithannulartubulesZhangJing，LiQing，ZhangChuanShan，etal.

4、nter>Departmentofpathology，XijingHospital，theFourthMilitaryMedicalUniversity，Xi’an710032.【Abstract】ObjectiveTodiscusstheclinicopathologicfeaturesofovariansex-cordtumorwithannulartubules（SCTAT）.Methods432casesofovariantumorwerestudi

5、edbycarefulmicroscopicobservation.Histochemˉicalmethodwasalsousedforstudy.Combiningclinicaldata，wesummarizedclinicopathologicfeaturesofSCTAT.ReˉsultsThreecasesofSCTATwerefoundin432casesofovariantumor.AlltumorsoccurredinthejuvenileoryoungfemalewithoutPoutz-Je

6、gherssyndrome.Clinicalsymptomwasturbulenceofincretion.Twocaseshadmetastasistotheretroperitoneumand（or）supraclavicularlymphnode.Grossexaminationrevealedthattumorswereyellowish，andunilateralwithsmoothsurface.Onetumorshowedvaryingdegreesofcysticdegenerationonse

7、ction.Microscopicexˉaminationshowedsimpleorcomplexannulartubuleswithprominentbasementmembranes.Thecytoplasmofthecellwaspale，andthenucleiwereroundness.ComparedwiththeprimarySCTAT，thecellsinmetastasizingtumorshadvaryingdegreesofatypia.Mitoticfigureswereusually

8、morethan4/10HPF.Simpleorcomplexannulartubulesweredecreasingmarkedly.PASstainingshowedpositivereactionforacidophilicsubstanceintubulesandbasementmemˉbranesaroundtubules.Gorden-Sweetstainingshowed