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1、软药原理与新药设计（Principleofsoftdruganddesignofnewdrug）N...n...Twenty-firstvolume..firstissue..fifty-eighthpagesHEBEIJOURNALOFINDUSTRIALVol.21..No.1..P.58Totaleighty-third....2004SCIENCE&TECHNOLOGYSum83....2004Articlenumber:1008..1534(2004)01..0058..03PrincipleofsoftdruganddesignofnewdrugWangShuyue1,YinHon
2、gjun2,ChenJinghong31..(HebeiMedicalUniversitySchoolofmedicineinHebei,Shijiazhuang.050017;2..ShijiazhuangYilingpharmaceuticalLimitedbyShareLtd,HebeiShijiazhuangZhuang050038.3..NewdrugresearchanddevelopmentcenterofNorthChinaPharmaceuticalGroup,Hebei,Shijiazhuang.050015)Toexploretheprincipleofsoftdrugp
3、rincipleinnewdrugresearch,andtopromotethedevelopmentofnewdrugresearch,throughtheliteraturesearchanalysisratioCompareandgeneralizethemeaning,classificationandtypicalcasesofsoftdrugsandtheprincipleofsoftmedicineinthenewdrugdesignUniversalapplication.Theprincipleisbasedonthemetabolismmechanismofeffecti
4、vedrugsforthedesignofnewdrugs.Itischaracterizedbyone-stepmetabolism,inactivationandcontractioninvivoTheinvivoprocessoftheshortmedicineseparatestheefficacyofthemedicinefromthetoxicandsideeffectsofthemedicine,andimprovesthetherapeuticindexofthemedicine.It'smorebrandnewDrugdiscoveryisoflowdifficulty,lo
5、wriskandhighhitrate.Itisanimportantapproachtothestudyofnewdrugs.Keyword:softdrugprinciple;newdrugdesign;metabolisminvivoCLCnumber:R97..documentidentificationcode:AWiththeimplementationofdrugpatentlaw,China'spharmaceuticalenterprisesusherinWithnewchallengesandopportunities,newdrugresearchhasshiftedfr
6、omimitationtoinnovationIthasbecomeaconsensus,accordingtoChina'snationalconditions,todevelopthosestructuraltypesDrugsknownorsuperiortoorsimilartoexistingproductsDirectionofattack[1].Theauthoronceontheprincipleofprodrug[2]..me..TooPrinciplesofMedicine[3],biologicalelectronics,etc.][4]etalinnewdrugrese
7、archanddesignTheapplicationhasbeenstudied,andnowtheprincipleofsoftmedicineisdiscussedApplicationofnewdrugdesign.TheprincipleofsoftmedicineistostudymetabolisminthebodyBasedonthemetabolicmechanism,theac
