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1、体内药物分析中色谱技术的应用[1（Applicationofchromatographictechniqueindruganalysisinvivo[1）217~218..[19],ZhaoXiaoping,LiHanzhi,DuXiaoyi,etal.CytochromeP4502C19genepolymorphismRelationshipwithgastriccancersusceptibility.Chinesecancerclinic,2000,27(7):488~490..[20]WeiXingSHi,Shu..Qi
2、ngChen..FrequenciesofpoormetabolizersOfcytochROMeP4502C19inesophaguscancer,Stomachcancer,LungcancerandbladdercancerinChinesepopulation..WorldJGastroentErol,2004,10(13):1961~1963..ApplicationofchromatographictechniqueindruganalysisinvivoWangGuangyin,sunLing1,QianChen2
3、(ShengliHospitalofShengliOilfield,Shandong,Dongying;257055;1..ShandongInstituteofpharmaceuticalindustry,Shandong,Ji'nan250100,China);2..Schoolofpharmacy,ShenyangPharmaceuticalUniversity,Liaoning,Shenyang110016)Abstract:inthispaper,somenewchromatographictechnologies,s
4、uchassupercriticalfluidchromatography,capillaryelectrophoresis,chiralchromatographyandgel,havebeenreviewedforinvivodruganalysisTheapplicationprogressofbeamchromatography,molecularchromatography,solidphasemicroextractioncombinedwithchromatography,massspectrometry,chro
5、matographyandchromatographywerereviewedTheprospectanddevelopmentdirectionoftechnologyinvivodruganalysisaretodevelopnewdetectiontechnologyandtorealizeitscontinuity,automationandcombinationbymeansofcomputerAndintelligent.Keywords:invivodruganalysis,biologicalsamples,ch
6、romatographytechniques,colormethods,etc.CLCnumber:O657..7..Documentidentificationcode:A..Articlenumber:1672-7738(2009)06-0355-04ApplicationsofchromatographictechniqueinbiopharmaceuticalanalysisWANGGuang..Yin,SUNLing1,QIANChen2(ShengliHospitalofShengLiOilField,DongYin
7、g257055;1..ShandongInstituteofPharmaceuticalIndustry,Ji..Nan250100;2..ShenyangPharmaceuticalUniversity,Shenyang110016)ABSTRACT:AdvanceinRecentapplicationsofnewChromatogRaphlctechniqueincludingSFC(supercriticalfluidChrOmatog..)Raphy),CE(capillaryelectrophoresis),CC(ch
8、iralchromatography),MC(micellarChrOmatoGRaphy),MBC(molecularbioChroma..)Tography),andCSPME(chromatography-solid..Phasemlcroextracti
