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1、Oestrogens,MoodandIntroductoryarticleCognitionArticleContents.IntroductionOFXAlmeida,MaxPlanckInstituteofPsychiatry,Munich,Germany.CerebralReceptorsforOestrogensGLConde´,MaxPlanckInstituteofPsychiatry,Munich,Germany.SexualDifferentiationoftheBrain.Cyc
2、licalSecretionofOestrogens.TherapeuticManipulationsoftheOestrogenMilieuOestrogensaresteroidhormonesthatactthroughspecificreceptorsinthebrainto.RoleofOestrogensinFemaleSexualBehaviourinfluencesexualbehaviour,aswellasmoodandcognition.Oestrogenactionsinc
3、lude.OestrogensandMoodalterationsofneuronalexcitability,neurotransmittersynthesisandmetabolism,neuronal.RoleofOestrogensinCognitioncircuitryandneuronalsurvival,oneorallofwhichmaycontributetotheireffectsonmood.Summaryandcognition.Introductionmiscarriag
4、esbutsubsequentlywithdrawnbecauseofitscarcinogenicproperties,isagoodexampleofahighlyOestrogensaresteroidhormonesbestknownfortheirrolepotentnonsteroidaloestrogen.Thephyto-oestrogensingametematuration,thedevelopmentofsecondary(plant-derivedcompoundswith
5、oestrogenicactivity)sexualcharacteristics,andmetabolic,skeletalandcardio-representanotherclassofnonsteroidaloestrogen,albeitvascularphysiology.Theireffectsonsexualbehaviourareweakones.Thesecompounds,chieflyrepresentedbyalsowellknown,buttheirotherneurotr
6、opicactions,whichisoflavones,forexamplecoumoestrol(Figure1c)andincludeeffectsonneuronaldifferentiationandfunction,genistein(Figure1d),arefoundinmostlegumes(particu-havebeenrecognizedonlymorerecently.Oestrogensarelarlyclover,lentils,chickpeasandavarietyof
7、beans,historicallyconsideredtobe‘femalesexhormones’inviewincludingsoy,mung,black,Limaandadukibeans).TheofthefactthattheyareproducedprimarilybytheovaryJapanesearrowroot,kudzu,reportedlycontainssomeofandplayacrucialroleinprocreativeprocessesinthethehigh
8、estlevelsofisoflavones.Resveratrol,foundinlargefemale.Itisnowclearthatoestrogensderivedfromamountsinredgrapeberryskins,wasrecentlyaddedtotheandrogenmetabolismalsoplayimportantrolesinmalelistofphyto-oestrogens;thiscompound(3,4’,5-trihydrox-physi
