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1、BioinformaticsAdaptiveComputationandMachineLearningThomasDietterich,EditorChristopherBishop,DavidHeckerman,MichaelJordan,andMichaelKearns,AssociateEditorsBioinformatics:TheMachineLearningApproach,PierreBaldiandSørenBrunakReinforcementLearning:AnIntroduct
2、ion,RichardS.SuttonandAndrewG.BartoPierreBaldiSørenBrunakBioinformaticsTheMachineLearningApproachABradfordBookTheMITPressCambridge,MassachusettsLondon,Englandc2001MassachusettsInstituteofTechnologyAllrightsreserved.Nopartofthisbookmaybereproducedinanyfo
3、rmbyanyelectronicormechanicalmeans(includingphotocopying,recording,orinformationstorageandretrieval)withoutpermissioninwritingfromthepublisher.ThisbookwassetinLucidabytheauthorsandwasprintedandboundintheUnitedStatesofAmerica.LibraryofCongressCataloging-i
4、n-PublicationDataBaldi,Pierre.Bioinformatics:themachinelearningapproach/PierreBaldi,SørenBrunak.—2nded.p.cm.—(Adaptivecomputationandmachinelearning)"ABradfordBook"Includesbibliographicalreferences(p.).ISBN0-262-02506-X(hc.:alk.paper)1.Bioinformatics.2.Mo
5、lecularbiology—Computersimulation.3.Molecularbiology—Mathematicalmodels.4.Neuralnetworks(Computerscience).5.Machinelearning.6.Markovprocesses.I.Brunak,Søren.II.Title.III.Series.QH506.B352001572.80113—dc212001030210SeriesForewordThefirstbookinthenewserie
6、sonAdaptiveComputationandMachineLearn-ing,PierreBaldiandSørenBrunak’sBioinformaticsprovidesacomprehensiveintroductiontotheapplicationofmachinelearninginbioinformatics.Thedevelopmentoftechniquesforsequencingentiregenomesisprovidingastro-nomicalamountsofDN
7、Aandproteinsequencedatathathavethepotentialtorevolutionizebiology.Toanalyzethisdata,newcomputationaltoolsareneeded—toolsthatapplymachinelearningalgorithmstofitcomplexstochas-ticmodels.BaldiandBrunakprovideaclearandunifiedtreatmentofstatisti-calandneuralnet
8、workmodelsforbiologicalsequencedata.Studentsandre-searchersinthefieldsofbiologyandcomputersciencewillfindthisavaluableandaccessibleintroductiontothesepowerfulnewcomputationaltechniques.Thegoalofbuildingsystemsthatcanadapttot
