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1、ChristianAlzheimerMolecularandCellularBiologyofNeuroprotectionintheCNSMolecularandCellularBiologyofNeuroprotectionintheCNSMolecularandCellularBiologyofNeuroprotectionintheCNSEditedbyChristianAlzheimerInstituteofPhysiologyUniversityofKielKiel,GermanyKluwerAcademic/PlenumPu
2、blishersNewYork,Boston,Dordrecht,London,MoscowLibraryofCongressCataloging-in-PublicationDataCIPappliedforbutnotreceivedattimeofpublication.MolecularandCellularBiologyofNeuroprotectionintheCNSEditedbyChristianAlzheimerISBN0-306-47414-XAEMBvolumenumber:513©2002KluwerAcademi
3、c/PlenumPublishersandLandesBioscienceKluwerAcademic/PlenumPublishers233SpringStreet,NewYork,NY10013http://www.wkap.nlLandesBioscience810S.ChurchStreet,Georgetown,TX78626http://www.landesbioscience.com;http://www.eurekah.comLandestrackingnumber:1-58706-104-X10987654321AC.I
4、.P.recordforthisbookisavailablefromtheLibraryofCongress.Allrightsreserved.Nopartofthisbookmaybereproduced,storedinaretrievalsystem,ortransmittedinanyformorbyanymeans,electronic,mechanical,photocopying,microfilming,recording,orotherwise,withoutwrittenpermissionfromthePubli
5、sher.PrintedintheUnitedStatesofAmerica.PREFACETheadultmammalianbrainisnotwellequippedforself-repair.Althoughneuronallossreinstallspartsofthemolecularmachinerythatisessentialforneuronaldevelopment,otherfactorsandprocessesactivelyimpederegenerationofthedamagedbrain.Manyther
6、apeuticeffortsthusaimtopromoteorinhibittheseendogenouspathways.Inaddition,moreradicalapproachesappearonthehorizon,suchasreplacementoflostneuronswithgraftedtissue.Neurorepair,however,isnotthetopicofthisbook.Here,wegoonestepbackinthesequenceofeventsthatleadeventuallytothede
7、miseofaneuronalpopulation.Thisbookfocusesonthepreciousperiodwhenaninitialdamagingeventevolvesintoavastlossofneurons.Thetimeframemightbehourstodaysinacutebraininjuryormonthstoyearsinchronicneurodegenerativediseases.Giventhelimitedcapacityofregeneration,protectingneuronstha
8、tareonthebrinkofdeathisamajorchallengeforbasicandclinicalneuroscience,withimplicationsforabroads
