白藜芦醇对兔骨关节炎作用的实验研究-药理学专业论文

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1、优秀毕业论文硕士学位论文中文摘要呈明显退行性变，Mankin’s评分显著增高，模型组血清、滑膜、骨关节液中NO含量和iNOS水平显著升高(P<0．05)；给予白藜芦醇后，Mankin’s评分显著降低，血清、滑膜、骨关节液中NO含量和iNOS水平显著降低(P<0．05)，D组与E组、F组之间比较差异有统计学意义(户

2、NOS水平，降低关节软骨中iNOS的阳性表达率，有可能成为改变OA进程的有效药物。关键词：白藜芦醇；骨关节炎；一氧化氮(No)；诱导型一氧化氮合成酶(iNOS)；Ⅱ精品参考文献资料优秀毕业论文硕士学位论文英文摘要Abstractobjective：TostudytheeffectofResveratrolandpossibleactionmechanismofResveratrolbythedeterminationofnitricoxideandinduciblenitricoxidesynthazelevelsinserum，synodalmem

3、brane，jointfluidsandarticularcartilageinOsteoarthritismodelRabbits．Methods：Preparing36NewZealandwhiterabbits，andtakhagsuction6rabbitsrandomlyasthenormalcontrolgroup(GroupA)．OtherrabbitsareconstructtheosteoarthritismodelrabbitabovethemodelsofdoingbyHulth．After4weeksofoperation，w

4、econfirmthebuildingoftheosteoarthritismodelissuccessfulbythealterofX-rayandpathology．Andthen，wetakethemodelrabitsinto5groups：osteoarthritismodelgroups(GroupB)；positivemedicamentcontrolgroup(GroupC；glucosaminesulphate，35mg·kgJ)；Thelowdosagetestmedicamentgroup(GroupD；resveratrol，

5、30mg·(kg·d)。1)；Themiddledosagetestmedicamentgroup(GroupE；resveratrol，60mg·(kg·d)。1)；Thehighdosagetestmedicamentgroup(GroupF；resveratrol，120mg·(蚝·d)‘1)；Thereare6rabbitsineachgroups．ThengroupA、Breceivedstomachirritationdailywithphysiologicalsaline(2ml·kg。1)andgroupD、E、Freceivedst

6、omachirritationdailywithResveratrolsolutionindifferentdosagefor4HI精品参考文献资料优秀毕业论文硕士学位论文英文摘要were35mg·kg～、30mg·蚝一、60weeks．DailydosageofC、D、E、Fmg·kg一、120mg·kg～respectively．After4weeks，killtherabbitsandcuttingthespecimenofthighbonecartilage．Takingthespecimendehydration，embeddingthes

7、pecimeninparaffinandsliceup．TodrywithH．E．WegradethetectologywiththechangofarticluarcartilagebythemethodsofMankin7Sunderthemicroscopeonthewayofdoubleblind．NOandiNOSinserumandsynorialmembraneandjointfluidsaremeasuredbynitratereductionmethod．WedetectthenumberofpositivecellsofiNOSb

8、ythemethodsofimmunohistochemistryassay．Studytheco．elat