张国强-异维a酸红霉素凝胶治疗轻中度寻常性痤疮临床观察

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1、异维A酸红霉素凝胶治疗轻中度寻常性痤疮72例临床观察张国强王文氢康瑞花王曙霞王正想高顺强河北医科大学第四医院皮肤科,河北石家庄050011通讯作者：高顺强，Gaoshunqiang@medmail.com.cn摘要目的：观察异维A酸红霉素凝胶治疗轻中度寻常性痤疮的疗效和安全性。方法：采用单盲随机阳性药物平行对照的临床试验。治疗组采用异维A酸红霉素凝胶，每晚外用1次；对照组河北医科大学第四医院皮肤科,河北石家庄050011zgq810328@sina.com通信作者：高顺强，Gaoshunqiang@medmail.com.cn采用他扎罗汀乳膏，每晚外用1次,连续应用56天。结

2、果：治疗后，两组皮损数目均减少。治疗组和对照组有效率分别为80.56%和65.71%，有统计学差异(P<0.05)；两组不良反应发生率分别为13.89%和21.34%，差异无统计学意义差异(P>0.05)。结论：异维A酸红霉素凝胶治疗轻中度寻常性痤疮安全有效，值得临床推广应用。关键词：痤疮；寻常性；治疗；异维A酸；红霉素ClinicalApplicationandEfficacyofIsotretinoinErythromycinGelfor72CasesofMildtoModerateAcneVulgarisZHANGGuo-qiang,WANGWen-qing,KANGR

3、ui-hua,WANGShu-xia,WANGZheng-xiang,GAOShun-qiangDepartmentofDermatology,theFourthAffiliatedHospitalofHebeiMedicalUniversity,Shijiazhuang050011，China[Correspondingauthor:]GAOShun-qiang，Gaoshunqiang@medmail.com.cnAbstract:Objective:Toevaluatetheefficacyandsafetyofisotretinoinerythromycingelin

4、thetreatmentofmildtomoderateacnevulgaris.Methods:Byasingle-blindrandomizedcontrolledmethod,atotalof142160patientswithmildtomoderateacnevulgariswereassignedtooneofthefollowingtwogroups:thetrailgroupwhichwastreatedwithisotretinoinerythromycingel(7280cases),whilethecontrolgroupwastreatedwithta

5、zarotenecream(7080cases).Aftertreatmentfor56consecutivedayswitheachdrugrespectivelysmearedonthesurfaceindividuallypereverynight,theefficacyandsafetywereinvestigated.Results:Thenumberofskinlesionsinbothofthetwogroupswasreduced.Effectiverateforthetrialgroupwas80.56%,thecontrolgroupwas65.71%,w

6、ithsignificantdifferencebetweenthem(P<0.05).Theadversereactionswere13.89%%and21.34%inthetrialandcontrolgrouprespectively,withnosignificantdifferencebetweenthem(P>0.05).Conclusion:Isotretinoinerythromycingelisasafeandmoreeffectivedruginthetreatmentofmildtomoderateacnevulgariscomparedwithtaza

7、rotenecream.Keywords:acneAcne;vulgarisVulgaris;treatmentTreatment;isotretinoinIsotretinoin;erythromycinErythromycin寻常性痤疮，是皮肤科常见的一种慢性毛囊皮脂腺炎症性疾病。2009年9月至－2010年3月，我本科应用异维A酸红霉素凝胶治疗寻常性痤疮72例，取得了满意疗效，现报告如下：。1资料与方法1.1临床资料1.1.1入选标准：受试者年龄在18~35岁之间；临床症状和体征符合寻常性痤疮的诊