柔筋方对紧张型头痛血管舒缩功能影响临床和实验的研究

《柔筋方对紧张型头痛血管舒缩功能影响临床和实验的研究》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、膜潜伏期较模型组降低，柔筋方可以降低紧张型头痛模型大鼠头区肌肉筋膜的敏感性。（5）柔筋方临床治疗的总有效率为86.67%，明显改善头痛指数。结论：（1）NO与紧张型头痛的发病密切相关，ET可能与紧张型头痛的发病有关联，二者可能通过影响血管的舒缩功能障碍，影响头区肌肉和皮肤的痛阈值及头区肌筋膜痛敏感性来参与紧张型头痛的发作。（2）柔筋方汤剂能有效解除或缓解头痛，改善患者的临床症状，疗效确切。柔筋方汤能调节体内血浆NO、ET的含量，调节血管的舒缩功能可能是其对紧张型头痛发挥作用的机制之一。关键词柔筋方；

2、紧张型头痛；一氧化氮/内皮素；血管舒缩功能ClinicalandExperimentalResearchonthevasomotorfunctionofTTHinterferedbyRoujinfangTangSpeciality：InternalMedicineofTCMAuthor：XieLidongTutor：ChiefphysicianHuZhiqiangAbstractObjective：BymeasuringvasodilatorsubstanceNOandthecontractiono

3、fvascularmaterialcontentofEToftension-typeheadache（Tension-typeheadache，TTH）modelinratplasma,brainhomogenateandtension-typeheadacheinpatients，bythiswecanexploretherelationshipofvasomotorfunctionwithTTH;whileexploreRoujinDecoctionontheTTHoftheimpactofthe

4、Vasomotorfunctionfunction.Methods：（1）Animalexperiments：dividehealthyWisteranimalsintothreegroupsbyrandom：Controlgroup（injectedbysalineintheneck）；Modelgroup（injectedbyATPintheneck）；Roujinfanggroup（injectedbyATPintheneckandgavagedbyRoujinfangTang）.Mod

5、elingmethodisbothsemisinalneckintramuscularinjectionsofATP.Afterthetest，detecttheplasmaNO/ETlevelswithbloodfromabdominalofallrats.Make10%brainhomogenatefromtheleftbraintodetecttheNO/ETlevels.Clinicaltrials：Select30patientswithCTTHgivedRoujinfangTang，det

6、ectveintheplasmaNO/ETlevelsbeforeandtreatment（March2012-december2012）.ObserveclinicalefficacyofRoujinfangTang.Results：（1）TheplasmaandbrainhomogenateNOofratsmodelofTension-typeheadacheincreaseabnormally（comparedwiththecontrolgroup，p＜0.01）.RoujinfangTa

7、ngcanreaduceplasmaandhomogenateNOlevels（comparedwithmodeldrouprespectively，p＜0.05）.（2）AlthoughthehomogenateETlevelsofratsmodelgroupincrease，thisishavenosignifficancestatistically（comparedwiththecontrolgroup，p＞0.05）.ThehomogenateETlevelsratsofRoujinfang

8、grouphavenosignifficancestatistically（comparedwiththemodelgroup，p＞0.05）.AlthoughtheplasmaETlevelsofratsmodelgroupreaduce，thisishavenosignifficancestatistically（comparedwiththecontrolgroup，p＞0.05）.AlthoughthehomogenateETlev