进展期胃癌术中行区域性缓释化疗安全性评价

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1、进展期胃癌术中行区域性缓释化疗安全性评价【摘要】目的探讨进展期胃癌术中腹腔内行区域性植入5�氟尿嘧啶缓释化疗的临床疗效及用药安全进行分析评价。方法将60例进展期胃癌患者均进行手术根治切除术后并随机分为两组，治疗组：30例患者给予术中行区域性缓释化疗；对照组30例患者与治疗组患者术后均进行常规全身化疗，并对其两组患者治疗后临床疗效进行疗效评价及安全性评价。结果疗效判定治疗组：完全缓解8例占26�7%、部分缓解11例占36�7%、疾病稳定7例占23�3%、疾病进展4例占13�3%。对照组：完全缓解5例占1�7%、部分缓解9例占30�0%、疾病稳定11例占

2、36�7%、疾病进展5例占16�7%。两组患者在治疗后腹腔相关并发症与化疗毒副作用无显著差异。结论进展期胃癌术中腹腔内行区域性植入5�氟尿嘧啶缓释化疗，患者耐受性良好，用药后临床疗效增加而未见明显的全身、局部不良反应。【关键词】进展期胃癌；区域缓释化疗；5�氟尿嘧啶缓释剂；疗效评价；不良反应Advancedgastriccancerintraoperativeregionalsafetyevaluationofsustained�releasechemotherapyHEXing�chang.DepartmetnofGeneral5SurgeryTh

3、eFirstPeople�sHospitalofShangqiucity476100,China【Abstract】ObjectiveTodiscussadvancedgastriccancerimplantedintheabdominalcavityofregionalexperts5�Fluorouracilchemotherapyefficacyandsustained�releasedrugsafetyanalysisandevaluation�Methods60casesofadvancedgastriccancerpatientsunde

4、rwentradicalsurgicalresectionwererandomlydividedintotreatmentgroups:30patientsweretreatedwithintraoperativeregionalslow�releasechemotherapy,controlgroupof30patientswithtreatmentgrouppatientsareroutinechemotherapy,andtwogroupsofpatientsaftertheirclinicalefficacyevaluationandsafe

5、tyevaluation�ResultsDeterminetheefficacyofthetreatmentgroups:completeremissionin8casesaccountedfor26�7%,partialresponse11casesaccountedfor36�7%,sevencasesofstabledisease23�3%,diseaseprogressionwasfourcases(13�3%)�Controlgroup:5caseswere(1�7%)completeremission,partialremissionin

6、9cases5accountedfor30�0%,stabledisease11casesaccountedfor36�7%,diseaseprogression,fivecasesof16�7%�Twogroupsofpatientsafterabdominal�relatedcomplicationsinthetreatmentofchemotherapysideeffectswithnosignificantdifference�ConclusionAdvancedgastriccancersurgeryintheabdominalcavity

7、implantationofregionalexperts5�Fluorouracilsustained�releasechemotherapy,thepatientiswelltolerated,clinicalefficacyaftertreatmentnosignificantincreaseinsystemicandlocaladversereactions.【Keywords】Advancedgastriccancer;Regionalreleasechemotherapy;5�Fluorouracilreleaseagent;Evalua

8、tion;Adversereactions作者单位：476100河南省商丘市第一人民医院普外科胃癌仍属于人类