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1、晚期糖基化终末产物对高血压及其合并早期肾损害相关性分析作者：俞晓军,袁国裕,邓爱玲单位：舟山市人民医院心内科，浙江?舟山晚期糖基化终末产物对高血压及其合并早期肾损害相关性分析作者：俞晓军，袁国裕，邓爱玲单位：(舟山市人民医院心内科，浙江?舟山316000)【关键词】晚期糖基化终末产物高血压早期肾损害AssociationofSerumAdvancedGlycosylationEndProducts(AGEs)andEarlyRenalDamageinEssentialHypertension(EH)Pa
2、tients.YUXiao_jun,YUANGuo_yu,DENGAi_ling.DepartmentofCardiology,ZhoushanPeople'sHospital,Zhejiang316000,China [Abstract]ObjectiveThepurposeofthisstudyis,bymeasuringtheserumlevelsofAGEsandurinemicroalbumin(mALB)inbothhypertensivepatientsandhealthypeoplet
3、oprobetherelationshipofAGEs,EHandtheearlyrenaldamageofEHandtoprovidesometheorybaseofthepathogenesisofEHandthepreventionandtreatmentofearlyrenaldamageinEH.Methods100EHpatients(42caseswithnormalmALBlevel，and58caseswithhighermALBlevel)wereselectedasEHgroup,
4、and41healthypeoplewereasnormalcontrolgroup.Therewasnostatisticalsignificancedifferenceinage,sex,bloodglucose,bloodlipids,creatinineamongthesethreegroups.Radioimmunoassay(RIA)andenzymelinkedimmunosorbentassay(ELISA)testwereusedtodetectthemALBlevelinthemor
5、ningurineandtheserumAGEslevelinallobjects.ResultsComparedwiththecontrolgroup,theserumAGEslevelinEHpatients(bothinnormalmALBgroupandabnormalmALBgroup)wassignificantlyhigher(P<0.001);andtheserumAGEslevelinEHabnormalmALBgroupwasmarkedlyhigherthanthatinEH
6、normalmALBgroup(P<0.001).LinearcorrelationanalysisshowedAGEsconcentrationwasnotablypositivecorrelatedwithSBP,PPandmALB(r=0.448_0.687,P<0.001);mALBconcentrationwassignificantlypositivecorrelatedwithSBP,PP(r=0.271_0.354,P<0.001).ConclusionsAGEs,SB
7、Pparticipatedintheprocessofhypertensiverenaldamage.AGEsandSBP,PPhadasignificantpositivecorrelation.SBPincreasedasAGEslevelincreased. [Keywords]Advancedglycationendproducts;Hypertension;Renaldysfunction 高血压(EH)是危害人类健康的常见病，可导致心、脑、肾等靶器官损害，重者可致死、致残[1]，肾脏是高
8、血压损害的重要靶器官之一[2]。目前认为内皮损伤、血管重塑、脂质代谢紊乱参与了EH及其合并征的发生发展。大量实验研究表明：血清晚期糖基化终末产物(AGEs)不仅在糖尿病及糖尿病肾病的发生、发展中起到重要作用，而且在心血管病中也起重要作用[3]。本文通过测定高血压病患者与正常人血清AGEs及尿微量白蛋白(mALB)的水平，探讨AGEs与EH及其早期肾功能损害的关系，为高血压发病机制及其早期肾功能损害防治研究提供理论依据。 1资料和方法 1
