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1、细胞凋亡研究进展（Researchprogressofapoptosis）ResearchprogressofapoptosisAbstract:Cellapoptosis,oncosisandnecroticcelldeathisirreversiblecellinjuryfunctionaldefinition,apoptosisisoneofthecelldeath,thetotalendchangesandnecrosisoccurredinthelivingonbehalfoflocaltis
2、sueaftercelldeath,isakindofmorphologicaldiagnosis.Inadditiontocellapoptosis,thereisanotherformofcelldeathornecrosislikedeath,said:"theoncosisoncosis"(oncosis),namelydeath(swellingdeath),wascharacterizedbycelldamageprocessofcytoplasmicswellingandkaryolysi
3、s.Althoughtherearestillmanyproblemsandeventhekeyquestionsarenotclear,buttheresearchinrecentyearsthebiochemicalreactionmechanisminapoptosissignaltransduction,cellapoptosisandapoptosisgeneregulationandotheraspectshavemadesignificantprogress.Keywords:apopto
4、sis,mitochondrialcysteineproteaseItisgenerallyacceptedthatapoptosisplaysanimportantroleincancerandotherdiseases.Ithasbeenwidelystudiedinmanybiologicalfields.Since1972,Kerrproposedtheconceptofcellapoptosis,fromlate80sbegantobecomearesearchhotspotintumoret
5、iology,pathology,understandingofapoptosisgradually,themolecularmechanismofapoptosisoccurredmoreandmorethoroughunderstanding,butalsofoundthatthisprocessisnotassimpleasoriginallythought,butcontainsacomplicatedregulatorymechanismthe.Thestabilityoforganismen
6、vironmentdependsnotonlyontheproliferationanddifferentiationofcells,butalsoontheapoptosisofcells.Apoptosis(apoptosis),alsoknownasprogrammedcelldeath,isoneofthemostimportantbiologicalphenomenainbiology.Fromnematodestohighermammals,fromembryostoadults,fromp
7、hysiologytopathology,frombirthtodeath,differentcellsinthebodyhavemoreofthisformofdeath.Morethan100yearsago,CarlVogthadfoundthisformofdeath.In1972,Kerretal.Reproposedthestudyandnamedapoptosis(apoptosis).Later,newinsightshavebeenmadeinthefieldsofmorphology
8、andbiochemistryofapoptosis.Recentstudieshavemadeclearprogressin3areas.First,fromthestudyofsmallnematode(C.elegans)apoptosisregulatinggene,confirmedapoptosisiscontrolledbygeneticdevelopment,amongwhichCed-9,Ced-3andCed-4gene
