t淋巴细胞亚群与铜绿假单胞菌医院感染的关系研究

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1、T淋巴细胞亚群与铜绿假单胞菌医院感染的关系研究-4?浙江预防医学2005年第l8卷第5期ZhejiangPreyMed,May2006,VolI8,No.5T淋巴细胞亚群与铜绿假单胞菌医院感染的关系研究张志华卢欢明翁炳焕【摘要】目的研究T淋巴细胞亚群(CD;,CD;,cD)与铜绿假单胞茁医院感染的关系,为临床合理治疗和预防铜绿假单胞菌感染提供实验依据.方法用APAAP法检测和比较铜绿似单胞菌院感组与非铜绿单胞菌院感组及正常对照组的CD[,CD;,CDE值,观察抗生素和免疫增强剂两者结合治疗铜绿假单胞菌医院感染的效果与cD,CD;,CW值变化的关系.结果铜

2、绿似胞菌院感组在使用抗生索和免疫增强剂治疗前及经治疗无效者CD;,CDg,cD值均明最低于非铜绿假单胞菌院感组及正常对照组(P<0.0J),经治愈后则CD;,CDZ,CD;值恢复正常,与非铜绿假单胞菌院感组及正常对照组_午}j比均无监着性差异(P>O.05)结论铜绿假单胞茁医院感染常伴有CD;,CDZ,CDa*值减少而导致的免疫功能低下,应使用抗生券或免疫增强剂两者结合治疗;临床上CD3+,CD;,CD8+值减少的患者,应防止铜绿假单胞菌医院感染的发生.【关键词】T淋巴细胞亚群;医院感染:铜绿似单胞菌;相关性中图分类号:R197.323文献标

3、识码:A文章编号:1007.0931(2006)05.O0O4.03CorrelationsbetweenTLymphocyteSubsetandNosoeomlalInfectionofPseudomonasAeruginosaZHANGZhi?hzta,LUHLtan—ruing,WENGBing—huan.(TheXia@'People'Hospital,Xia@',Zhejiang,315300,Chirm.)【Abstract】ObjectiveTounde~tandthecorrelationbetweenTlymphocytesubset(

4、CD3.cD4.CDs)andnosocomialinfectionofpseudomonasaomginosa.thentoprovideexperimentalevidenceforpreventingandtreatingnosoeomialinfectionofpseudomonasaeln3~nosa.MethodsAccordingtotheinfectionstatusofp~udomonasaerugiaosa,subjectsweredividedintothreegroups:infectiongroup,non-infectiong

5、roupandnormalcontrolgroup.TheirlevelsofCD3,CD,,CDBcellsweredetectedbyalkalinephosphaseantialkalinephosphatase(APAAP)andcomparedamongdifferentgroups,thenthecorrelationbetweenthechangesofTlymphocytesubsetandtheeffectofthecombinationtherapyofantibioticsandimmun0p0fentjatorswasinvest

6、igated.ResultsThelevelsofCD3,CI)4.CDacellsofinfectiongroupbeforetreatmentorthosewhohadnoresponseaftertreatmentinthesamegroupweresignificantlylowerthanthoseofnon—infectiongroupandcontrolgroup(P(O.O1).Aftertreatment,thelevelsofCD3,CD4.cD8ofinfectiongroupbecamenormalandhadnosignific

7、antdifferencewiththoseofnon—infectiongroupandcontrolgroup(P>005).ConclusionsNosocomialinfectionofpseudomonasaeruginosisusuallyaccompaniedwithimmunodcfieieneythatisleadedbylowTlymphocytesubset.andshouldbetreatedbythecombineduseofantibioticsandinununopotentlators.Thepatientswith

8、lowlevelsofCD,CD4,CD8cellsshouldbepreven