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1、参松养心胶囊治疗高血压并室性期前收缩的疗效实用药物与I临床2011年第14卷第3期PracticalPharmacyAndClinicalReme~es,2011,Vo1.14,No.3?263?参松养心胶囊治疗高血压并室性期前收缩的疗效关健,吴小玲[摘要]目的观察参松养心胶囊治疗高血压并室性期前收缩的疗效及安全性.方法选取高血压并室性期前收缩患者70例,随机分成参松养心胶囊组(治疗组)35例及慢心律组(对照组)35例,分别给予参松养心胶囊(4次,3&/d)及慢心律(150mg/d,3>R./d)治疗1个月,观察两组患者治疗前后临床症状,心电图,动态心电图变
2、化及不良反应.结果治疗组患者临床症状总好转率为91.43%,对照组为74.29%,两组差异有统计学意义(P<0.05);治疗组抗心律失常动态心电图示总有效率为77.14%,对照组为71.43%,两组差异无统计学意义(P>0.05);治疗组的不良反应明显少于对照组(P<0.05).结论参松养心胶囊治疗高血压并室性期前收缩疗效确切,毒副作用少,对患者临床症状及服药耐受性的改善均优于慢心律.[关键词]参松养心胶囊;高血压;室性期前收缩;慢心律Effect0fshensOngyangxincapsuleonventricularprematurebeatthes
3、sentialhy—pertensionGUANJian,wuXiao—ling(DepartmentofCardiology,AffiliatedHospitalofGuangdongMedicalCollege,Zhanjiang524001,China)[Abstract]ObjectiveToinvestigatetheefficacyandsafetyofshensongyangxincapsuleinthetreatmentofventricularprematurebeat(VPB)withessentialhypertension(EH).Methods7
4、0patientswithVPBandEHwereen—rolledandrandomlyassignedintotwogroups:35patientsintreatmentgroupweretreatedwithshensongyangxincapsule(4capsuleseachtime,threetimesaday);35patientsincontrolgroupweretreatedwithmexilitine(150mgeachtime,threetimesaday),withatreatmentcourseofonemonthforbothgroups.
5、Varietyofclincialsymptoms,electrocardio—gramanddynamicelectrocardiogrambeforeandaftertreatmentandthesideeffectswereobservedinbothgroups.Re-suitsTheeffectiverateoftreatmentgroupandcontrolgroupwere91.43%and74.29%(P<0.05);Fromtheresultofdynamicelectrocardiogram.thegeneraleffectiverateofVP
6、Bwere77.14%and71.43%intreatmentgroupandcontrolgrouprespectively(尸>0.05);Sideeffectsintreatmentgroupweresignificantlylessthanthoseincontrolgroup(P<0.05).ConclusionShensongyangxincapsulehasexactefficacyinthetreatmentofVPBandEHwithoutserioussideeffect,andithasbettereffectandtoleranceth
7、anmexilitine.Keywords:Shensongyangxincapsule;Essentialhypertension;Ventricularprematurebeat;Mexilitine室性期前收缩是临床上最常见的一种心律失常,高血压是室性期前收缩发生的常见原因之一,但有效控制血压并不能控制室性期前收缩及改善临床症状,需要给予抗心律失常治疗.由于长期使用临床上常规的抗心律失常药物的不良反应较大(尤其是对心脏具有抑制作用).为探索疗效确切而不良反应少的抗心律失常药,笔者观察了中成药参松养心胶囊治疗高血压病并室性
