基于疾病中医证候分类的中药药效评价研究思路和方法论文

《基于疾病中医证候分类的中药药效评价研究思路和方法论文》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、基于疾病中医证候分类的中药药效评价研究思路和方法论文吕爱平,刘学文,丁晓蓉【摘要】中药的临床应用建立在辨证的基础上，因此其药效评价也应该建立在中医证候分类的基础之上。通过药效学实验阐明中药治疗疾病的药效作用特点及其机制，揭示中药作用机制的科学内涵，是中药现代化和国际化的必然要求，也是探索药物作用靶点，指导临床合理用药的关键所在。如何利用成熟疾病动物模型，并明确其证候特征，是中药药效评价载体研究的关键问题。随着生物医学的发展.freelacodynamicevaluationonChineseherbalmedicineistoclarifythecharacteristicsan

2、dactionmechanismsofChineseherbalmedicine.ItisarequestfortraditionalChinesemedicine(TCM)modernizationandakeypartinclinictofocusonpharmacodynamicevaluationonChineseherbalmedicine.Inpresent,alotofresultsonChineseherbpharmacodynamicevaluationarenotsatisfied.MeanainreasonisthattheyignoretheTCMbasi

3、ctheory,edifferentiation.TheclinicalapplicationofChineseherbsmustbeestablishedinaccordanceedifferentiation,i.eChineseherbhasitsoofpharmacodynamicevaluationonChineseherbistoclarifytheChineseherbactionbasedonTCMsyndromedifferentiation.1SyndromeclassificationandChineseherbpharmacodynamicevaluati

4、onSyndromeclassificationisakindofodelandefficacybasisinTCM［2］.ChinesemedicinalformulaisthemainforminclinicalapplicationofChineseherbs.Itisthekeyfactortosetupsyndromedifferentiationsystemulabasedonsyndromedifferentiation.Theprocessofsyndromedifferentiationistoclearupsyndromeclassificationfirst

5、,andthentoestablishprinciplebasedonsyndrometypeandtodeterminetheformulabasedonprinciplefinally.Thereby,thefinetherapeuticactionofChineseherbcanbedisplayed［3］.Itisacertainrequestforsyndromedifferentiationtobuild“formulasyndrome”correspondence［4］.“Formulasyndrome”correspondenceisthepremiseand

6、basisforinducingChineseherbefficacy.Thehighlightis“selectingcertainformulabasedoncertainsyndrome”［5］.IgnoringsyndrometypetoevaluateChineseherbactionsinglehandedlycannotdisplayobjectively.Thustheresultscannotguidetheclinicalpractice.Hence,theclinicalapplicationofChineseherbcloselyrelatestosyn

7、dromedifferentiationandthepotencyofChineseherbshouldbeexhibitedunderthespecialsyndrometype.2AnimalmodelandpharmacodynamicevaluationonChineseherbalmedicineThefinalpurposeofselectingdrugistogetfinetherapeuticeffects.Themainaimforpharmacodynamic