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1、2型糖尿病患者血清瘦素、神经肽Y和肿瘤坏死因子α的变化106中田临床康复笫'9卷筹3期2005.01.21出版Ch/nese1ournalofClinicalRehabilitation,January212005VoL9No.32型糖尿病患者血清瘦素,神经肽Y和肿瘤坏死因子Ot的变化★韩睿,田浩明,宋滇平,童南伟,冉兴无?基础研究?韩睿,宋滇平,昆明医学院第一附属医院内分泌科,云南省昆明市【wwW.zgkkf.tom650o3l田浩明,童南伟,冉兴无,四川大学华西医院内分泌科,四川省成都市6l0O
2、4l韩睿★,女,1971年生,云南省昆明市人,汉族,2001年四川大学毕业,硕士,讲师,主要从事糖尿痛的研究.liyenlinhan@yahoo.eom.cn电话:+86-871-4149180中圈分类号:R587.1文t标识码:A文章编号:l671—5926(2005)03—0106—02收稿日期:2004—08—11修回日期:2004—09—20(12/NH/YH)Chlmlg~of鲫mlepfin.neuropepfldeYandtimlorⅡesfactoralphainty】pe2diab
3、eticHanRui,TianHao--ming,S0ngan?ping.TongNon-wei,RanXing-wuHanRui.SongOian?ping,DepamnentofEndocrinology,FirstAffiliatedHospitalK1l越ni】MedicalCollege,Kunming650031,YunnanProvince,ChinalionHao-ming,TongNan-wei.RanXing-wu,DepartmentofEndocrinolo-gy,W皓tCh
4、inaHospital,SiehuanUniversity,Chengdu610041,SiehuanProvince,ChinaHonRui*,Female,HanNationality,Bornin1971inKunmingCity,Yun-nanProvince.China,GraduatedfromSichuanUniversityin20ol,Master,Lecturer.Researchdirection:diabetes.I/yanlinhan@yahoo.eom.cnTeleDho
5、ne:+86.87l-4149180Reedved:2004—08一llAccepted:2004一O9—2OAbstractAⅡ.I:1-0investigatethechangeandsignificanceof8erttlnleptin(LEP),neuropeptideY(NPY),ttl/nornecrosisfactor-a(TNF-a)levelsintype2di-abeticpatientsandnondiabeticpatientswithsimilarage,genderand
6、bodymassindex(BMI).咂lTHoDS:Seventy.8ixhospitalizedpatientswithtype2diabeteswereBe-lectedfromWestChinaHospital,SiehuanUniversitydurin8March1999andFebruary2000.Outofthe76diabeticpatien~,43werepreliminarilydiag-nosed(preliminarydiagnosisgroup)and33finally
7、diagnesed(finaldiagnosisgroup).Fortyhealthyvolunteers(20malesand20females)wereselectedfromclinicinthesamehospirala8controls(controlgroup).Bloodsampleswerecollectedandassayedinthe8ubiect8ofthethreegroups,andthelevelsofserugnleptin.NPYandTNF-aweredetermi
8、nedwithradioimmunoassay.R]瞵町LTs-①Thelevelsoffastin8plasmaglucose(FPG),2-hourpostpran-dialplasmaghoose(PPG),glycohemoglobin(A1C),fastinginsulin,triglyc?efideandcholesterolinthetype2diabeticsweresignificantlyhigherthanth0∞inthecoa~h(allP&
